DRSC/TRiP Functional Genomics Resources

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Protein Alignment APAF1 and wds

DIOPT Version :9

Sequence 1:NP_863651.1 Gene:APAF1 / 317 HGNCID:576 Length:1248 Species:Homo sapiens
Sequence 2:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster


Alignment Length:330 Identity:93/330 - (28%)
Similarity:165/330 - (50%) Gaps:33/330 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   599 NKKNITNLSRLVVRP----------HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI 653
            :..:.:|.|.|.|:|          ||.||....||.:|:.:||..|||.::::.|..|:....|
  Fly    46 SNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 110

Human   654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 718
            ..|:..:...|:|:|.|.:.:.|.||.:|:|...||:.:.|...||..|.||:|...|:  |:.:
  Fly   111 SGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSN--LIVS 173

Human   719 GSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV 783
            ||.|..:::||:...:|..|:..|::.|:...|:.|..|:.|.|.||..::||..|....|::  
  Fly   174 GSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-- 236

Human   784 KQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC- 846
                  ::|....:..:    .:|.:|..|:.|. .|.:.|:| ::.|...:.:|||.:. :|| 
  Fly   237 ------IDDDNPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCI 289

Human   847 --DFSPQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906
              :||......:|:.|: ..|.:||..|:..|...:||...|......|..:...:::  :|:||
  Fly   290 FANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTI 354

Human   907 RLWET 911
            :||::
  Fly   355 KLWKS 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APAF1NP_863651.1 CARD_APAF1 7..92 CDD:260034
NB-ARC 129..374 CDD:395745
APAF1_C 453..587 CDD:407760
WD40 607..910 CDD:238121 91/319 (29%)
WD 1-1 613..652 15/48 (31%)
WD40 repeat 623..655 CDD:293791 11/31 (35%)
WD 1-2 655..694 12/38 (32%)
WD40 repeat 660..697 CDD:293791 12/36 (33%)
WD 1-3 697..738 14/40 (35%)
WD40 repeat 703..741 CDD:293791 12/37 (32%)
WD 1-4 741..780 12/38 (32%)
WD40 repeat 746..791 CDD:293791 12/44 (27%)
WD 1-5 796..836 8/40 (20%)
WD40 repeat 802..870 CDD:293791 20/72 (28%)
WD 1-6 838..877 13/42 (31%)
WD 1-7 880..910 8/31 (26%)
WD40 repeat 885..939 CDD:293791 7/29 (24%)
Interpropeller linker. /evidence=ECO:0000250 910..921 0/2 (0%)
WD 2-1 922..958
WD 2-2 959..998
WD40 961..1234 CDD:238121
WD40 repeat 964..990 CDD:293791
WD 2-3 1001..1040
WD40 repeat 1006..1030 CDD:293791
WD 2-4 1042..1080
WD40 repeat 1047..1082 CDD:293791
WD 2-5 1083..1122
WD40 repeat 1089..1124 CDD:293791
WD 2-6 1125..1164
WD40 repeat 1130..1172 CDD:293791
WD 2-7 1175..1212
WD40 repeat 1180..1213 CDD:293791
WD 2-8 1213..1248
wdsNP_001245503.1 WD40 64..358 CDD:238121 87/309 (28%)
WD40 repeat 75..112 CDD:293791 12/36 (33%)
WD40 repeat 118..154 CDD:293791 12/35 (34%)
WD40 repeat 159..195 CDD:293791 13/37 (35%)
WD40 repeat 202..237 CDD:293791 11/42 (26%)
WD40 repeat 244..280 CDD:293791 8/40 (20%)
WD40 repeat 288..325 CDD:293791 10/36 (28%)
WD40 repeat 331..357 CDD:293791 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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