Protein Alignment p115 and USO1

DIOPT Version :10

• Sequence 1: NP_572417.1
• Gene: p115 / 31698
• FlyBaseID: FBgn0040087
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_001276978.1
• Gene: USO1 / 8615
• HGNCID: 30904
• Length: 973
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 412/857 - (48%)
• Similarity: 552/857 - (64%)
• Gaps: 46/857 - (5%)

  Fly     1 MEFLKSGIKTVLGSTEPGQQPSAAETVEKLVDRVYSSTLLEDRRDACRALKALSRKYRIEVGAQG 65
            |.||:.    |:|....|.|.:.|||::||.|||.|||||:|||:|.||||:||:|||:|||.|.
Human     1 MNFLRG----VMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQA 61

  Fly    66 MPPLVQVLQNDGQDAEIISYALDTLCNVVTSEEFDE----EADNPT-VSVNVGEQFTEMFIKTPE 125
            |..|:.|||.|..|:|||.||||||.|::::||.:|    |.:|.| .|.::|.||||:|||..|
Human    62 MEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVDDVEEENSTRQSEDLGSQFTEIFIKQQE 126

  Fly   126 HVTLVMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRNDVL 190
            :|||::..|:|:||.||...::|:|||:.....::|.:|||||||||:|||||.|||||||||.:
Human   127 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGV 191

  Fly   191 LLLIELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQFFKE 255
            |||..||:.|..|||||||||||:||.:|:.|||.||||||||||||||.||||||:|||.||||
Human   192 LLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKE 256

  Fly   256 GSYIQRLSPMFELSQDAEEVGWSPQKVSNFHCLLQVVRALVTPSNQQQVVAACQRVMQKSRLLHA 320
            ||||||:.|.||:..  |..|||.|||:|.|.:||:||.||:|:|.....::||:.|.:..||..
Human   257 GSYIQRMKPWFEVGD--ENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQ 319

  Fly   321 LCEILMSSGVPADILTETINAVAEVVRGDRDNQDELGRVMAPSSPPRPAIVVLLMSMINEKQLLA 385
            ||.|||::||||||||||||.|:||:||.:.|||....|.|||:|||||||||||||:||:|...
Human   320 LCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFV 384

  Fly   386 LRCAVLYCFECFLYRNADGQRAVVQTLLPSSASDV-SALSTGQLLCTGLFSTDALANWFSAVALM 449
            |||||||||:||||:|..||..:|.|||||:.... :::|.|||||.||||||:|:||.:||||.
Human   385 LRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALA 449

  Fly   450 HSLVENVALKEELLRVLLATPGGQKPITLLEQCTNLMQQ------ERYRLQSKVGLLMLLSLWLA 508
            |:|.||...||:||||.|||..|..|::||:||||::.|      ...::|::|||||||..||:
Human   450 HALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGDKIDRRGSKIQTRVGLLMLLCTWLS 514

  Fly   509 HCPGAVKALLETQGTMAYLTAQLCSNEHDEREFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQL 573
            :||.||...|.....:.:||.|:..|..:| |.||||:||.|:|:.|.||||||....:|.:.||
Human   515 NCPIAVTHFLHNSANVPFLTGQIAENLGEE-EQLVQGLCALLLGISIYFNDNSLESYMKEKLKQL 578

  Fly   574 IIKRIGQESFCSKLAEVSRHEAYSRACKQAQIRAKSAGELLLDFEYCKLYKGLEALIAKLV--SG 636
            |.||||:|:|..||..:|:||.||||.::.|....|...::.|.|:.||.|.||.:|.|.:  |.
Human   579 IEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSS 643

  Fly   637 FDVDGIELTELTLSSEASALVSQYKGIIRGMDAQIQALQQSSKELEQENAELKEKLGEEQSLKAQ 701
            .:....|..:.||....: :|:.||.:||..|.|::.|:|....|:.:|.:|:..:.::.|...|
Human   644 EEDKKEEEVKKTLEQHDN-IVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQ 707

  Fly   702 LLDQNTLLKAQLGA-STGQVQSAQGAEATPPNEEELNAARYQANMYFAENIRLTKEL-------- 757
            ..||..|||.|||. :..|...::||:......||:...|.:     .|.::..:||
Human   708 HKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREE-----IEELKRNQELLQSQLTEK 767

  Fly   758 ETLRQQLSAEKQSADAAQDSLAAMQKDQEDLLEL----------LADQEAKLTRYEEAGSTNTLP 812
            :::.:.:.:.:.|....|.|.....:|.|.:.||          |..|..::|:.:.........
Human   768 DSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQK 832

  Fly   813 TSNVAPSVPAAG 824
            |...|.||...|
Human   833 TEAFAKSVEVQG 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p115	NP_572417.1	Arm_vescicular	275..334	CDD:465861	30/58 (52%)
		Uso1_p115_head	361..632	CDD:461460	147/277 (53%)
		Uso1_p115_C	690..832	CDD:461461	34/154 (22%)
USO1	NP_001276978.1	Arm_vescicular	274..333	CDD:465861	30/58 (52%)
		Uso1_p115_head	351..639	CDD:461460	152/288 (53%)
		SMC_prok_B	<670..>907	CDD:274008	43/180 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	774..794		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	937..973