DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p115 and USO1

DIOPT Version :9

Sequence 1:	NP_001284992.1	Gene:	p115 / 31698	FlyBaseID:	FBgn0040087	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_010225.1	Gene:	USO1 / 851501	SGDID:	S000002216	Length:	1790	Species:	Saccharomyces cerevisiae

Alignment Length:	918	Identity:	210/918 - (22%)
Similarity:	378/918 - (41%)	Gaps:	149/918 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QQP---SAAETVEKLVDRVYSSTLLEDRRDACRALKALSRKYRIEVGAQGMPPLVQVLQNDGQDA 80
            |||   |..||:..|.|||.:|||:.|||.|...|||.||:||..|.|.|:.||:..|:.|..|.
Yeast     9 QQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDE 73

  Fly    81 EIISYALDT-LCNVVTSEEFDE---------------EADNPTVSVNVGEQ-------FTEMFIK 122
            :.:...|:| |...:..:..|:               :..:|.|.....||       ..:...:
Yeast    74 DSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQ 138

  Fly   123 TPEHVTLVMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRN 187
            :.:.:.|::.:.:..:|.:|...|||:.::::.:..:.:..::..|..:|.::.||.|..|.||:
Yeast   139 SEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRD 203

  Fly   188 DVLLLLIELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQF 252
            :.:|||:.:...:.::||:|||||.|:|||.|:.|||...|.:||.|||.|:.|:||.|:|||..
Yeast   204 EAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTL 268

  Fly   253 FKEGSYIQRLSPMFE--LSQDAEEVGWSPQKVSNFHCLLQVVRALVTPSNQQQVVAACQRVMQKS 315
            |.|...:.:|:.:..  :||| |...|:.|::.|.:..|.:|...|.|.|  .|....|..:..|
Yeast   269 FLETGNLPKLAHLLSEPISQD-EVFFWNDQRIVNINTALDIVSLTVEPGN--TVTTKHQNALLDS 330

  Fly   316 RLLHALCEILMSSGVPADILTETINAVAEVVRGDRDNQDELGRVMAPSSPPR------------- 367
            .:|..:..:.....:|..:....:...|.:||.:...|.|..::..|...|.
Yeast   331 SVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIK 395

  Fly   368 --PAIVVLLMSMI--NEKQLLALRCAVLYCFECFLYRNADGQR----AVVQTLLPSSASDV--SA 422
              |.:.:|:..|:  |.......|.|.....:.:...|.|.||    ..|| |..:|.::|  :|
Yeast   396 LIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQ-LCNNSTNNVGDNA 459

  Fly   423 LSTG----------------------------QLLCTGLFSTDALAN------WFSAVALMHSLV 453
            ...|                            ..|...|.:.||..|      :|:....|....
Yeast   460 KENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQ 524

  Fly   454 ENVALKEELLRVLLATPGG-----QKPI----TLLEQCTNLMQQERYRLQSKVGLLMLLSLWLAH 509
            ::....|||..:......|     ::|:    |:.|..|..:.....|:  .:..|..|..||.
Yeast   525 QDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRI--PISYLTFLIYWLF- 586

  Fly   510 CPGAVKALLETQGTMAYLTAQLC-SNEHDEREFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQL 573
              |..||..:.....:.:.:.|. |.:..:.:..::.:...|:|:..:|:....|..::| ..:.
Yeast   587 --GDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKE-YFEF 648

  Fly   574 IIKRIGQESFCSKLAEVSRHEAYSRA-CKQAQIRAKSAGELLLDFEYCKLY------KGLEALIA 631
            |.|.:|::::.|::.:..:...:|:. ..:..|......|..|...|...|      :.:..:..
Yeast   649 ITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRT 713

  Fly   632 KLVSGFDVDGIELTELTLSSEASALVSQYKGIIRGMDAQIQALQQSSKE----LEQENAELKEKL 692
            .|....|.:.|.........:.....::.||.|..:..:.::..::..|    |..|:.||.||.
Yeast   714 ALSHDPDEEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKY 778

  Fly   693 GEEQSLKAQLLDQNTLLKAQL---GASTGQVQSAQGAEATPPNEEELNAARYQANMYFAENI--R 752
            ....|..:.|.:..::|:.:|   ..|..::...:....|...|.:.....|::.::..|:.  .
Yeast   779 QILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKT 843

  Fly   753 LTKELETLRQQLSAEKQSAD-----------------AAQDSLAAMQKD--------QEDLLELL 792
            |.|.|||:   ||.:|::.|                 |.:::...:||:        |::...|.
Yeast   844 LEKGLETI---LSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLK 905

  Fly   793 ADQEAKLT 800
            .|..||:|
Yeast   906 EDIAAKIT 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p115	NP_001284992.1	Uso1_p115_head	354..632	CDD:309827	60/351 (17%)
p115	NP_001284992.1	Uso1_p115_C	690..832	CDD:309829	29/141 (21%)
USO1	NP_010225.1	Uso1_p115_head	366..715	CDD:398505	61/355 (17%)
		M_group_A_cterm	783..>915	CDD:411361	27/134 (20%)
		Smc	898..1733	CDD:224117	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346529
Domainoid	1	1.000	144	1.000	Domainoid score	I991
eggNOG	1	0.900	-	-		E1_KOG0946
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2754
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004607
OrthoInspector	1	1.000	-	-		oto99298
orthoMCL	1	0.900	-	-		OOG6_103848
Panther	1	1.100	-	-	LDO	PTHR10013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1694
SonicParanoid	1	1.000	-	-		X3226
TreeFam	1	0.960	-	-
	13	12.730