DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p115 and GC6

DIOPT Version :9

Sequence 1:	NP_001284992.1	Gene:	p115 / 31698	FlyBaseID:	FBgn0040087	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_566820.1	Gene:	GC6 / 822375	AraportID:	AT3G27530	Length:	914	Species:	Arabidopsis thaliana

Alignment Length:	901	Identity:	240/901 - (26%)
Similarity:	417/901 - (46%)	Gaps:	136/901 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKSGIKTVLGSTEPGQQPSAAET-VEKLVDRVYSSTLLEDRRDACRALKAL---SRKYRIEVGAQ 64
            |.|..|.|:|......|.|..:: :::|:||:.:.||.:|||.|...|:::   |...::..||.
plant     3 LASRYKGVVGMVFGDNQSSNEDSYIQRLLDRISNGTLPDDRRTAIVELQSVVAESNAAQLAFGAA 67

  Fly    65 GMPPLVQVLQNDGQDAEIISYALDTLCNVVTSEEFDEEADNPTVSVNVGEQFTEMFIKTPEHVTL 129
            |.|.:|.:|::...|.|::..||:||...:|.   .:.|......|......:::..:..|::||
plant    68 GFPVIVGILKDQRDDLEMVRGALETLLGALTP---IDHARAQKTEVQAALMNSDLLSREAENITL 129

  Fly   130 VMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRNDVLLLLI 194
            ::..|:|.||.||...:|::|:|:.|....||:.||.:|.|:::|||:|.| ||||||:.||||.
plant   130 LLSLLEEEDFYVRYYTLQILTALLMNSQNRLQEAILTTPRGITRLMDMLMD-REVIRNEALLLLT 193

  Fly   195 ELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQFFKEGSYI 259
            .||:....|||||.||.||:::|.|::|||.|||.:||:|||.||.|||:::||||...:|....
plant   194 HLTREAEEIQKIVVFEGAFEKIFSIIKEEGGSDGDVVVQDCLELLNNLLRSSSSNQILLRETMGF 258

  Fly   260 QRLSPMFELSQDAEEVGWSPQKVSNFHCLLQVVRALV------TPSNQQQVVAACQRVMQKSRLL 318
            :.:..:.:|.....:  ::.||..|....|:.:..|:      .|......:|....::||..|.
plant   259 EPIISILKLRGITYK--FTQQKTVNLLSALETINMLIMGRADTEPGKDSNKLANRTVLVQKKLLD 321

  Fly   319 HALCEILMSSGVPADILTETINAVAEVVRGDRDNQDEL-GRVMAPSSPPRPAI-----VVLLMSM 377
            :.|...:.|...|..:...|...:.:::.|...|:|.| .:|:.......||:     ::|..|.
plant   322 YLLMLGVESQWAPVAVRCMTFKCIGDLIDGHPKNRDILASKVLGEDRQVEPALNSILRIILQTSS 386

  Fly   378 INEKQLLALRCAVLYCFECFLYRNADGQRAVVQTLLP-------SSASDVSALSTGQLLCTGLFS 435
            |.|      ..|..|.|:.|..:|.:||..:..||:|       ....|...:|.|.:|..||.|
plant   387 IQE------FVAADYVFKTFCEKNTEGQTMLASTLIPQPHPTSRDHLEDDVHMSFGSMLLRGLCS 445

  Fly   436 TDA---LANWFSAVALM-HSLVENVALKEELLRVLLATP----GGQKP-----ITLLEQCTNLMQ 487
            .:|   |.....|.::: |.:.:|:..||:.|:::|.:|    |..:|     :..|...:::..
plant   446 GEADGDLETCCRAASILSHVVKDNLRCKEKALKIVLESPMPSMGTPEPLFQRIVRYLAVASSMKS 510

  Fly   488 QERYRLQSKVG-------LLMLLSLWLAHCPGAVKALLETQGTMAYL-------TAQLCSNEHDE 538
            :|:   .|.:|       :|.||..|...||.||:..|:::..:.:|       .|.:|
plant   511 KEK---SSTLGKSYIQQIILKLLVTWTVDCPTAVQCFLDSRHHLTFLLELVTDPAATVC------ 566

  Fly   539 REFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQLIIKRIGQESFCSKLAEVSRHEAYSRACKQA 603
                ::|:.:.|:|.|:.:|.:...|:....:...:.:::|..|:.||..|:.....:|.:.|..
plant   567 ----IRGLASILLGECVIYNKSIENGKDAFSVVDAVGQKMGLTSYFSKFEEMQNSFIFSPSKKPP 627

  Fly   604 Q-----IRAKSAGELLLD--FEYCKLYKGLEALIAKLVSGFDVDGIELTELTLSSEASALVSQYK 661
            |     .|..:..|..::  .|..::.||.|. ...|:|.||...|            .||...:
plant   628 QGYKPLTRTPTPSEAEINEVDEVDEMVKGNED-HPMLLSLFDASFI------------GLVKSLE 679

  Fly   662 GIIRGMDAQIQALQQSSKELEQENAELKEKLGEEQS-----LKA----------QLLDQNTLLKA 711
            |.||  :..:....:...|:....|:|::|.||.:.     |||          .||.:|..| |
plant   680 GNIR--ERIVDVYSRPKSEVAVVPADLEQKSGENEKDYINRLKAFIEKQCSEIQNLLARNAAL-A 741

  Fly   712 QLGASTGQVQSAQGAEATPPNEEELNAARYQANMYFAENIRLTKELETLRQQLSAEKQSADAAQD 776
            :..||:|:.:.:||:|..                  |..:....::|::|::|....|..:..:.
plant   742 EDVASSGRNEQSQGSEQR------------------ASTVMDKVQMESIRRELQETSQRLETVKA 788

  Fly   777 SLAAMQKDQEDLLELLADQEAKLTRYEEAGSTNTLPTSN--VAPSVPA-AGGGSPI 829
            ..|.::.:......:.|..|..|....:|  .|:|..:|  :...|.: .||.||:
plant   789 EKAKIESEASSNKNMAAKLEFDLKSLSDA--YNSLEQANYHLEQEVKSLKGGESPM 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p115	NP_001284992.1	Uso1_p115_head	354..632	CDD:309827	74/324 (23%)
p115	NP_001284992.1	Uso1_p115_C	690..832	CDD:309829	35/158 (22%)
GC6	NP_566820.1	Uso1_p115_head	359..683	CDD:368165	81/355 (23%)
		BicD	<704..>837	CDD:370639	32/153 (21%)
		Uso1_p115_C	788..903	CDD:368167	13/57 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I1114
eggNOG	1	0.900	-	-		E1_KOG0946
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I1019
OMA	1	1.010	-	-		QHG55450
OrthoDB	1	1.010	-	-		D1273987at2759
OrthoFinder	1	1.000	-	-		FOG0004607
OrthoInspector	1	1.000	-	-		oto2834
orthoMCL	1	0.900	-	-		OOG6_103848
Panther	1	1.100	-	-	LDO	PTHR10013
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840