Protein Alignment p115 and Uso1

DIOPT Version :10

• Sequence 1: NP_572417.1
• Gene: p115 / 31698
• FlyBaseID: FBgn0040087
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: XP_006250812.1
• Gene: Uso1 / 56042
• RGDID: 621604
• Length: 966
• Species: Rattus norvegicus
• Alignment Length: 848
• Identity: 409/848 - (48%)
• Similarity: 550/848 - (64%)
• Gaps: 32/848 - (3%)

  Fly     1 MEFLKSGIKTVLGSTEPGQQPSAAETVEKLVDRVYSSTLLEDRRDACRALKALSRKYRIEVGAQG 65
            |.||:.    |:|....|.|.:.|||::||.|||.|||||:|||:|.||||:||:|||:|||.|.
  Rat     1 MNFLRG----VMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQA 61

  Fly    66 MPPLVQVLQNDGQDAEIISYALDTLCNVVTSEEFDEEADNPT-VSVNVGEQFTEMFIKTPEHVTL 129
            |..|:.|||.|..|:|||:||||||.|:::::|.:|..:|.| .|.::|.||||:|||.||:|||
  Rat    62 MEHLIHVLQTDRSDSEIIAYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQPENVTL 126

  Fly   130 VMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRNDVLLLLI 194
            ::..|:|:||.||...::|:|||:......:|.:|||||||||||||||.||||:||||.:|||.
  Rat   127 LLSLLEEFDFHVRWPGVRLLTSLLKQLGPPVQQIILVSPMGVSKLMDLLADSREIIRNDGVLLLQ 191

  Fly   195 ELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQFFKEGSYI 259
            .||:.|..|||||||||||:||.:|:.|||.||||||||||||||.||||||:|||.||||||||
  Rat   192 ALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYI 256

  Fly   260 QRLSPMFELSQDAEEVGWSPQKVSNFHCLLQVVRALVTPSNQQQVVAACQRVMQKSRLLHALCEI 324
            ||:...||:..  |..|||.|||:|.|.:||:||.||:|:|.....::||:.|.:..||..||.|
  Rat   257 QRMKAWFEVGD--ENPGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTI 319

  Fly   325 LMSSGVPADILTETINAVAEVVRGDRDNQDELGRVMAPSSPPRPAIVVLLMSMINEKQLLALRCA 389
            ||::|:||||||||||.|:||:||.:.|||....|.|||:|||||||||||||:||:|...||||
  Rat   320 LMATGIPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCA 384

  Fly   390 VLYCFECFLYRNADGQRAVVQTLLPSSASDV-SALSTGQLLCTGLFSTDALANWFSAVALMHSLV 453
            |||||:||||:|..||..:|.|||||:.... :::|.|||||.||||||:|:||.:||||.|:|.
  Rat   385 VLYCFQCFLYKNEKGQGEIVATLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQ 449

  Fly   454 ENVALKEELLRVLLATPGGQKPITLLEQCTNLMQQ------ERYRLQSKVGLLMLLSLWLAHCPG 512
            .|...||:||||.|||..|..|::||:||||::.|      ...::|::|||||||..||::||.
  Rat   450 GNATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGDKIDRRGSKIQTRVGLLMLLCTWLSNCPI 514

  Fly   513 AVKALLETQGTMAYLTAQLCSNEHDEREFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQLIIKR 577
            ||...|.....:.:||.|:..|..:| |.||||:||.|:|:.|.||||||....:|.:.|||.||
  Rat   515 AVTHFLHNSANVPFLTGQIAENLGEE-EQLVQGLCALLLGISIYFNDNSLENYTKEKLKQLIEKR 578

  Fly   578 IGQESFCSKLAEVSRHEAYSRACKQAQIRAKSAGELLLDFEYCKLYKGLEALIAKLV--SGFDVD 640
            ||:|::..||..:|:||.||||.::.|....|...::.|.|:.||.|.||.:|.|.:  |..:..
  Rat   579 IGKENYIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDK 643

  Fly   641 GIELTELTLSSEASALVSQYKGIIRGMDAQIQALQQSSKELEQENAELKEKLGEEQSLKAQLLDQ 705
            ..|..:.||....: :|:.||.:||..|.|::.|:|....|:.:|.:|:..:.::.|...|..||
  Rat   644 KEEEVKKTLEQHDN-IVTHYKNMIREQDLQLEELKQQVSTLKCQNEQLQTAVTQQASQIQQHKDQ 707

  Fly   706 NTLLKAQLGAST-GQVQSAQGAEATPPNEEELNAARYQANMYFAENIRLTKEL---ETLRQQLSA 766
            ..|||.|||... .|...:.||:......||::..|.:.....:..:.|..:|   :|:.:.|.:
  Rat   708 YNLLKVQLGKDNHHQGSHSDGAQVNGIQPEEISRLREEIEELRSHQVLLQSQLAEKDTVIENLRS 772

  Fly   767 EKQSADAAQDSLAAMQKDQEDLLEL----------LADQEAKLTRYEEAGSTNTLPTSNVAPSVP 821
            .:.|..:.|.......:|.|.:.||          |..|..::||.:...|........:|.|||
  Rat   773 SQVSGMSEQALATCSPRDAEQVAELKQELSALKSQLCSQSLEITRLQTENSELQQRAETLAKSVP 837

  Fly   822 AAG 824
            ..|
  Rat   838 VEG 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p115	NP_572417.1	Arm_vescicular	275..334	CDD:465861	29/58 (50%)
		Uso1_p115_head	361..632	CDD:461460	145/277 (52%)
		Uso1_p115_C	690..832	CDD:461461	36/149 (24%)
Uso1	XP_006250812.1	Arm_vescicular	271..329	CDD:465861	29/57 (51%)
		Uso1_p115_head	347..635	CDD:461460	150/288 (52%)
		Smc	<666..>937	CDD:440809	45/175 (26%)