DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p115 and Uso1

DIOPT Version :9

Sequence 1:	NP_001284992.1	Gene:	p115 / 31698	FlyBaseID:	FBgn0040087	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_006535203.1	Gene:	Uso1 / 56041	MGIID:	1929095	Length:	966	Species:	Mus musculus

Alignment Length:	848	Identity:	409/848 - (48%)
Similarity:	550/848 - (64%)	Gaps:	32/848 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEFLKSGIKTVLGSTEPGQQPSAAETVEKLVDRVYSSTLLEDRRDACRALKALSRKYRIEVGAQG 65
            |.||:.    |:|....|.|.:.|||::||.|||.|||||:|||:|.||||:||:|||:|||.|.
Mouse     1 MNFLRG----VMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQA 61

  Fly    66 MPPLVQVLQNDGQDAEIISYALDTLCNVVTSEEFDEEADNPT-VSVNVGEQFTEMFIKTPEHVTL 129
            |..|:.|||.|..|:|||:||||||.|:::::|.:|..:|.| .|.::|.||||:|||.||:|||
Mouse    62 MEHLIHVLQTDRSDSEIIAYALDTLYNIISNDEEEELEENSTRQSEDLGSQFTEIFIKQPENVTL 126

  Fly   130 VMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRNDVLLLLI 194
            ::..|:|:||.||...::|:|||:......:|.:|||||||||:|||||.||||:||||.:|||.
Mouse   127 LLSLLEEFDFHVRWPGVRLLTSLLKQLGPPVQQIILVSPMGVSRLMDLLADSREIIRNDGVLLLQ 191

  Fly   195 ELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQFFKEGSYI 259
            .||:.|..|||||||||||:||.:|:.|||.||||||||||||||.||||.|:|||.||||||||
Mouse   192 ALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKTNNSNQNFFKEGSYI 256

  Fly   260 QRLSPMFELSQDAEEVGWSPQKVSNFHCLLQVVRALVTPSNQQQVVAACQRVMQKSRLLHALCEI 324
            ||:.|.||:.:  |..|||.|||:|.|.:||:||.||:|:|.....::||:.|.:..||..||.|
Mouse   257 QRMKPWFEVGE--ENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTI 319

  Fly   325 LMSSGVPADILTETINAVAEVVRGDRDNQDELGRVMAPSSPPRPAIVVLLMSMINEKQLLALRCA 389
            ||::|:||||||||||.|:||:||.:.|||....|.|||:|||||||||||||:||:|...||||
Mouse   320 LMATGIPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCA 384

  Fly   390 VLYCFECFLYRNADGQRAVVQTLLPSSASDV-SALSTGQLLCTGLFSTDALANWFSAVALMHSLV 453
            |||||:||||:|..||..:|.|||||:.... :::|.|||||.||||||:|:||.:||||.|:|.
Mouse   385 VLYCFQCFLYKNEKGQGEIVATLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQ 449

  Fly   454 ENVALKEELLRVLLATPGGQKPITLLEQCTNLMQQ------ERYRLQSKVGLLMLLSLWLAHCPG 512
            .|...||:||||.|||..|..|::||:||||::.|      ...::|::|||||||..||::||.
Mouse   450 GNATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGDKIDRRGSKIQTRVGLLMLLCTWLSNCPI 514

  Fly   513 AVKALLETQGTMAYLTAQLCSNEHDEREFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQLIIKR 577
            ||...|.....:.:||.|:..|..:| |.||||:||.|:|:.|.||||||....:|.:.|||.||
Mouse   515 AVTHFLHNSANVPFLTGQIAENLGEE-EQLVQGLCALLLGISIYFNDNSLENYTKEKLKQLIEKR 578

  Fly   578 IGQESFCSKLAEVSRHEAYSRACKQAQIRAKSAGELLLDFEYCKLYKGLEALIAKLV--SGFDVD 640
            ||:|:|..||..:|:||.||||.::.|....|...::.|.|:.||.|.||.:|.|.:  |..:..
Mouse   579 IGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDK 643

  Fly   641 GIELTELTLSSEASALVSQYKGIIRGMDAQIQALQQSSKELEQENAELKEKLGEEQSLKAQLLDQ 705
            ..|..:.||....: :|:.||.:||..|.|::.|:|....|:.:|.:|:..:.::.|...|..||
Mouse   644 KEEEVKKTLEQHDN-IVTHYKNMIREQDLQLEELKQQVSTLKCQNEQLQTAVTQQASQIQQHKDQ 707

  Fly   706 NTLLKAQLGAST-GQVQSAQGAEATPPNEEELNAARYQANMYFAENIRLTKEL---ETLRQQLSA 766
            ..|||.|||... .|.....||:......||::..|.:.....::...|..:|   ::|.:.|.:
Mouse   708 YNLLKVQLGKDNHHQGSHGDGAQVNGIQPEEISRLREEIEELKSQQALLQGQLAEKDSLIENLKS 772

  Fly   767 EKQSADAAQDSLAAMQKDQEDLLEL----------LADQEAKLTRYEEAGSTNTLPTSNVAPSVP 821
            .:.|..:.|.|.....:|.|.:.||          |..|..::||.:............:|.|||
Mouse   773 SQASGMSEQASATCPPRDPEQVAELKQELTALKSQLCSQSLEITRLQTENCELLQRAETLAKSVP 837

  Fly   822 AAG 824
            ..|
Mouse   838 VEG 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p115	NP_001284992.1	Uso1_p115_head	354..632	CDD:309827	148/284 (52%)
p115	NP_001284992.1	Uso1_p115_C	690..832	CDD:309829	36/149 (24%)
Uso1	XP_006535203.1	Arm_vescicular	269..329	CDD:376191	29/59 (49%)
		Uso1_p115_head	347..635	CDD:368165	151/288 (52%)
		SMC_prok_B	<666..>934	CDD:274008	45/175 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850129
Domainoid	1	1.000	312	1.000	Domainoid score	I1313
eggNOG	1	0.900	-	-		E1_KOG0946
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2754
Inparanoid	1	1.050	722	1.000	Inparanoid score	I627
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55450
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004607
OrthoInspector	1	1.000	-	-		oto92786
orthoMCL	1	0.900	-	-		OOG6_103848
Panther	1	1.100	-	-	LDO	PTHR10013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1694
SonicParanoid	1	1.000	-	-		X3226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790