DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and NEK9

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001316166.1	Gene:	NEK9 / 91754	HGNCID:	18591	Length:	991	Species:	Homo sapiens

Alignment Length:	304	Identity:	111/304 - (36%)
Similarity:	162/304 - (53%)	Gaps:	29/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GEESAGMDFSQKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEI 67
            |..:.|....|:.|. |..:.|:|.|:||.....|......|..||.::...|.|.:....::||
Human    37 GPRAGGGAAEQEELH-YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEI 100

  Fly    68 SVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLC 132
            .:|..|||.||:.||:|.::.  .::.|.:|.|.||:|...:.|.:.  :.|||..:...|||:.
Human   101 VILALLQHDNIIAYYNHFMDN--TTLLIELEYCNGGNLYDKILRQKD--KLFEEEMVVWYLFQIV 161

  Fly   133 RALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPEL 197
            .|:...|    ...|||||||..||||..|...||||:|||:.|..:.|.|.:.||||:||||||
Human   162 SAVSCIH----KAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPEL 222

  Fly   198 VKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFD-----QLSEKIAQGEFSRIPAI------YS 251
            .:|.||:.|||:|||||:::|:..|:     |.||     .|..||.||    |.|:      ||
Human   223 CQGVKYNFKSDIWAVGCVIFELLTLK-----RTFDATNPLNLCVKIVQG----IRAMEVDSSQYS 278

  Fly   252 TDLQEIIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPIL 295
            .:|.:::...|..|.||||..:.::..||:.:...|::.|..:|
Human   279 LELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	103/273 (38%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	103/272 (38%)
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..43		1/5 (20%)
		STKc_Nek9	51..308	CDD:270860	103/274 (38%)
		S_TKc	52..308	CDD:214567	103/272 (38%)
		RCC1 1	388..444
		RCC1	389..441	CDD:278826
		RCC1	444..495	CDD:278826
		RCC1 2	445..498
		RCC1	500..559	CDD:278826
		RCC1 4	563..627
		RCC1 5	628..680
		RCC1	628..676	CDD:278826
		RCC1 6	681..738
		Interaction with NEK6. /evidence=ECO:0000269\|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920