DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and PRAF1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_565144.1	Gene:	PRAF1 / 844030	AraportID:	AT1G76950	Length:	1103	Species:	Arabidopsis thaliana

Alignment Length:	530	Identity:	95/530 - (17%)
Similarity:	182/530 - (34%)	Gaps:	154/530 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 AVGCLVYEMCAL----------RPPFRGRAF---DQLSEKIAQGEFSRIPAIYSTDLQEIIAF-- 260
            ||.|.|:...|:          .....|:.|   |....::..|:  :.|.:..|.:..:|.:
plant   445 AVSCGVWHTAAVVEIIVTQSNSSSVSSGKLFTWGDGDKNRLGHGD--KDPRLKPTCVPALIDYNF 507

  Fly   261 -MLAVDHEQRPGI----EVIIRHPLVVRNISEL--DGKFPILVDSGEDFYTLPSGARLFEDEEED 318
             .:|..|....|:    :|......|...:..|  |||.|.||:.        ..|..|.:|...
plant   508 HKIACGHSLTVGLTTSGQVFTMGSTVYGQLGNLQTDGKLPCLVED--------KLASEFVEEISC 564

  Fly   319 GVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESI 383
            |.:...:.|...|.|::.:|...|      :...||..       ||:          |::.|::
plant   565 GAYHVAALTSRNEVYTWGKGANGR------LGHGDLED-------RKV----------PTIVEAL 606

  Fly   384 RRE---------------------ERAEERQ---VELAEERRRKKDQ------------EQQKRD 412
            :..                     ..||:.|   ..||....||:..            ..:|..
plant   607 KDRHVKYIACGSNYTAAICLHKWVSGAEQSQCSTCRLAFGFTRKRHNCYNCGLVHCHSCSSKKAF 671

  Fly   413 QELLKEAPSSPR--ALTQNIFDEVLK-TRLHAIRAQESLLQQKLEELQTR--EQELQLAEQRVQT 472
            :..|  |||:.|  .:..:.:.::.| :.::....:.|.:.:...|.:.|  :.|::||:.....
plant   672 RAAL--APSAGRLYRVCDSCYVKLSKVSEINDTNRRNSAVPRLSGENRDRLDKSEIRLAKFGTSN 734

  Fly   473 LE--RQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPA 535
            ::  :|:..|..:|.|.|                      ||: ::..|...|::.:|..|   .
plant   735 MDLIKQLDSKAAKQGKKT----------------------DTF-SLGRNSQLPSLLQLKDA---V 773

  Fly   536 PKSLNTLRKVTFK--------SPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDSGD-- 590
            ..::..:|:.|.|        |.:....:...:.||.:..|.  |..:|:...:.::.|....
plant   774 QSNIGDMRRATPKLAQAPSGISSRSVSPFSRRSSPPRSATPM--PSTSGLYFPVGIADNMKKTNE 836

  Fly   591 ----------SQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKPPITQ 645
                      :|..|..:|.......|....|.|.::|....:  ::|.:|..:.  |:|..|.|
plant   837 ILNQEIVKLRTQVDSLTQKCEFQEVELQNSVKKTQEALALAEE--ESAKSRAAKE--AIKSLIAQ 897

  Fly   646 --EQPAEVPP 653
              :...::||
plant   898 LKDVAEKLPP 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	16/89 (18%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	16/89 (18%)
PRAF1	NP_565144.1	PH_PLC_plant-like	14..124	CDD:270171
		ATS1	238..628	CDD:227511	39/215 (18%)
		FYVE	627..695	CDD:214499	13/69 (19%)
		COG1340	<828..909	CDD:224259	16/84 (19%)
		BRX_N	879..>908	CDD:404581	8/33 (24%)
		BRX	1022..1077	CDD:400608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010