DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and AT1G65920

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_176767.1	Gene:	AT1G65920 / 842904	AraportID:	AT1G65920	Length:	1006	Species:	Arabidopsis thaliana

Alignment Length:	700	Identity:	134/700 - (19%)
Similarity:	219/700 - (31%)	Gaps:	244/700 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESAGMDFSQKTLQDYEVLAVMGNGSF-------GTCYKVRDKSTGELFAWKGMNYDELDEAKCDA 62
            |.:|..|..:.:.|     |:| ||.       |..:.....|:|:||.:....:..|.....::
plant   376 EQSGSQFLTRKISD-----VLG-GSLTVLSVACGAWHTAIVTSSGQLFTYGSGTFGVLGHGSLES 434

  Fly    63 LV--SEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR----QRFEE 121
            :.  .|:..||:::                    ::...|.....|.||:.|..::    :...:
plant   435 VTKPKEVESLRRMK--------------------VISVSCGPWHTAAIVETANDRKFYNAKSCGK 479

  Fly   122 PYIW--------------RVLFQLCRALQVCHNKIP-------------NGTI------LHRDI- 152
            .:.|              |.|...|....:.|:.|.             :||:      :|..:
plant   480 LFTWGDGDKGRLGHADSKRKLVPTCVTELIDHDFIKVSCGWTLTVALSISGTVYTMGSSIHGQLG 544

  Fly   153 ------KPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHY---------------MSPE 196
                  |..|:.|   ||       |.|...:|   .||  |:.|.               |:.:
plant   545 CPRAKDKSVNVVL---GN-------LTRQFVKD---IAS--GSHHVAVLTSFGNVYTWGKGMNGQ 594

  Fly   197 LVKGRKYDRKSDV-------------------WAVGCLVYEM----------CALRPPFRGRAF- 231
            |..|...||.|.|                   .|..||..|:          |.....|..|..
plant   595 LGLGDVRDRNSPVLVEPLGDRLVESIACGLNLTAAICLHKEISLNDQTACSSCKSAFGFTRRKHN 659

  Fly   232 ---------DQLSEKIA--------QGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHP 279
                     :..|.|.|        :.:.||:.......|..|..|...|..:....     |..
plant   660 CYNCGLLFCNACSSKKAVNASLAPNKSKLSRVCDSCFDHLWSITEFSRNVKMDNHTP-----RMQ 719

  Fly   280 LVVRNISE-LDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMF---TEQYSFNEGYG 340
            :|.|.:|| |..|     .|..:...||...|..:.:...|.....|...|   :...|.|....
plant   720 MVTRRVSEDLTEK-----QSENEMQNLPQANRSSDGQPRWGQVSGPSLFRFDKISTSSSLNLSVS 779

  Fly   341 QRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRRE-----ERAEERQVELAEE- 399
            .||.|.|.:.|.        |...||...:..:|.  ::.::::|:     |:.||.|.||.:.
plant   780 ARRTSSTKISTS--------SESNKILTEEIERLK--AVIKNLQRQCELGNEKMEECQQELDKTW 834

  Fly   400 RRRKKDQEQQKRDQELL----------KEAPSSP--------RALTQNIFDEVLK----TRLHAI 442
            ...|::.|:.|..:|::          ||.||:|        .:....|||:.:.    |.:...
plant   835 EVAKEEAEKSKAAKEIIKALASKLQANKEKPSNPLKTGIACNPSQVSPIFDDSMSIPYLTPITTA 899

  Fly   443 RAQESLLQQKLEELQT----REQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRK 503
            |:|.. .:|.:|:..|    |:..::|.......:.|   ...||.|....|..|
plant   900 RSQHE-TKQHVEKCVTKSSNRDSNIKLLVDASPAITR---TGYLQNETQDSSAEQ---------- 950

  Fly   504 PAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKF 553
             .:.:....|.|              ...||..:  .||::|.| |.::|
plant   951 -VEQYEPGVYIT--------------FTALPCGQ--KTLKRVRF-SRKRF 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	64/377 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	63/376 (17%)
AT1G65920	NP_176767.1	PH_PLC_plant-like	14..126	CDD:270171
		ATS1	<291..646	CDD:227511	54/310 (17%)
		FYVE	639..699	CDD:366594	8/59 (14%)
		Smc	<798..>864	CDD:224117	13/67 (19%)
		BRX_N	839..874	CDD:372684	8/34 (24%)
		BRX	948..1001	CDD:369842	10/62 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010