DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and NEK1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001185224.1	Gene:	NEK1 / 841893	AraportID:	AT1G54510	Length:	612	Species:	Arabidopsis thaliana

Alignment Length:	635	Identity:	166/635 - (26%)
Similarity:	262/635 - (41%)	Gaps:	136/635 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.||.|..:|.||||:...||.|...:.:..|.:......:....:...|:.::.:::||.||:
plant     1 MEQYEFLEQIGKGSFGSALLVRHKHEKKKYVLKKIRLARQTQRTRRSAHQEMELISKMRHPFIVE 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            |....|.: |..|.||:..|.|||:||.::  :|....|:|..:.:.|.||...|:..|    :.
plant    66 YKDSWVEK-ACYVCIVIGYCEGGDMAQAIK--KSNGVHFQEEKLCKWLVQLLMGLEYLH----SN 123

  Fly   146 TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVW 210
            .|||||:|.:||||....:.:|||||||::|..| ...:|.||||.||.|||:....|..|||:|
plant   124 HILHRDVKCSNIFLTKEQDIRLGDFGLAKILTSD-DLTSSVVGTPSYMCPELLADIPYGSKSDIW 187

  Fly   211 AVGCLVYEMCALRPPFRGRAFDQ--LSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIE 273
            ::||.:|||..|:|.|  :|||.  |..||.:...|.:||.||...:.::..||..:.|.||...
plant   188 SLGCCIYEMAYLKPAF--KAFDMQALINKINKTIVSPLPAKYSGPFRGLVKSMLRKNPEVRPSAS 250

  Fly   274 VIIRHP------LVVR-NISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTE 331
            .::|||      |.|: .::.|..|            |||               |||.|:
plant   251 DLLRHPHLQPYVLDVKLRLNNLRRK------------TLP---------------PELPSS---- 284

  Fly   332 QYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVEL 396
                      :|:                        .||...|:|::             ....
plant   285 ----------KRI------------------------MKKAHFSEPAV-------------TCPA 302

  Fly   397 AEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQ 461
            ..||:.:.....:..:.|..::..||.:.:::.|.|..:::     .::.:|:.:::.....:..
plant   303 FGERQHRSLWNDRALNPEAEEDTASSIKCISRRISDLSIES-----SSKGTLICKQVSSSACKVS 362

  Fly   462 ELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVA 526
            :..||:..| |..|.|:........|..|.....:..||..:       .|...:....|:..||
plant   363 KYPLAKSSV-TSRRIMETGRRSDHLHPVSGGGTTSKIIPSAR-------RTSLPLTKRATNQEVA 419

  Fly   527 KLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNP-PPTG-----VPMQMSVSS 585
            ..|       ..:..|:.|  |||:    |.|..  |...|.|:.| .|..     .|||...||
plant   420 AYN-------PIVGILQNV--KSPE----YSINE--PQVDKIAIFPLAPYEQDIFFTPMQRKTSS 469

  Fly   586 NDSGDSQASSTRRKSILSLFGLSRGSKAT-----SKSLPSVNQVAQAAAT 630
            ..|..|..|.|:.|..:......:|.:..     |....|.:|.|.|.|:
plant   470 KSSSVSDRSITKDKCTVQTHTTWQGIQLNMVDNISDGSSSSDQNATAGAS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/270 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	98/269 (36%)
NEK1	NP_001185224.1	STKc_Nek	3..258	CDD:270855	98/264 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I1512
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		mtm947
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960