DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and AT5G42140

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001318728.1	Gene:	AT5G42140 / 834219	AraportID:	AT5G42140	Length:	1078	Species:	Arabidopsis thaliana

Alignment Length:	768	Identity:	142/768 - (18%)
Similarity:	252/768 - (32%)	Gaps:	202/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALV------SEISVLRQLQHPNIV 79
            |.:|..:.|.|:.....| :.|:::.|..:..:.:.:...|..:      |::.:.:.|: .|:|
plant   214 VSSVQSSSSHGSAPDDCD-ALGDVYIWGEVLCENVTKFGADKNIGYLGSRSDVLIPKPLE-SNVV 276

  Fly    80 QYYHH---------LVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRAL 135
            ...||         ||:|:.: |:...| .:||.|...:.:..:..|..|......:.|..|...
plant   277 LDVHHIACGVKHAALVSRQGE-VFTWGE-ASGGRLGHGMGKDVTGPQLIESLAATSIDFVACGEF 339

  Fly   136 QVC---------------HNK--IPNGTILHRDIKPANIFLDAAG----NAKLGDFGLARMLRRD 179
            ..|               ||.  :.:||.:...| |..|.....|    :...|.:..|.:....
plant   340 HTCAVTMTGEIYTWGDGTHNAGLLGHGTDVSHWI-PKRISGPLEGLQIASVSCGPWHTALITSTG 403

  Fly   180 QSFA---ASFVGTPHYMSPELVKGRKYDRKSDV--WAVGCLVYEMCALRPPFRGRAFDQLS---- 235
            |.|.   .:|....|.....:...|:.:..|.:  .||.|.|:...|:.......:...:|
plant   404 QLFTFGDGTFGVLGHGDKETVFYPREVESLSGLRTIAVACGVWHAAAIVEVIVTHSSSSVSSGKL 468

  Fly   236 ------EKIAQGEFSRIPAIYSTDLQEII---AFMLAVDHEQRPGI----EVIIRHPLVVRNIS- 286
                  :|...|...:.|.:..|.:..:|   ...:|..|....|:    :|......|...:.
plant   469 FTWGDGDKSRLGHGDKEPRLKPTCVSALIDHTFHRVACGHSLTVGLTTSGKVYTMGSTVYGQLGN 533

  Fly   287 -ELDGKFPILVD----------------------SGEDFYTLPSGA--RLFEDEEEDGVHPELSS 326
             ..|||.|.||:                      |..:.:|...||  ||...:.||...|.|..
plant   534 PNADGKLPCLVEDKLTKDCVEEIACGAYHVAVLTSRNEVFTWGKGANGRLGHGDVEDRKAPTLVD 598

  Fly   327 TMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEE 391
            .: .|::..|...|..       ||..:                       .|::.:...|:::.
plant   599 AL-KERHVKNIACGSN-------FTAAI-----------------------CLHKWVSGTEQSQC 632

  Fly   392 RQVELAEERRRKKDQ------------EQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRA 444
            .....|....||:..            ..:|..:..|...|..|..:..:...::.|.....|.:
plant   633 SACRQAFGFTRKRHNCYNCGLVHCHSCSSKKSLKAALAPNPGKPYRVCDSCHSKLSKVSEANIDS 697

  Fly   445 QESLLQQKLEELQTR--EQELQLAEQRVQT---LERQMQEKLLQQEKHTCSCRQPIAPPIPPRKP 504
            :::::.:...|.:.|  :.|::||:..:.:   |.:|:..:..:|.|..
plant   698 RKNVMPRLSGENKDRLDKTEIRLAKSGIPSNIDLIKQLDNRAARQGKKA---------------- 746

  Fly   505 AKSHHDDTYCTIELNETSPTVAK---LNLATL----PAPKSLNTLRKVTFKSPQKFVTYGIENMP 562
                  ||:..:..::|..|..|   .|:|.|    |.|       .||..|.:....:...:.|
plant   747 ------DTFSLVRTSQTPLTQLKDALTNVADLRRGPPKP-------AVTPSSSRPVSPFSRRSSP 798

  Fly   563 PPAVKPAVNPPPTGVPMQMSVSSNDSGD--------------SQASSTRRKSILSLFGLSRGSKA 613
            |.:|.|.    |..|.:..|.|..:|..              :||.|.|.:..:..|.:.:..|.
plant   799 PRSVTPI----PLNVGLGFSTSIAESLKKTNELLNQEVVRLRAQAESLRHRCEVQEFEVQKSVKK 859

  Fly   614 TSK--SLPSVNQVAQAAATRV-------QRPPLAVKPPITQEQPAEVPPVANL 657
            ..:  ||.:.......||..|       .:...|:.||...|  ||....|||
plant   860 VQEAMSLAAEESAKSEAAKEVIKSLTAQVKDIAALLPPGAYE--AETTRTANL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	58/317 (18%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	58/317 (18%)
AT5G42140	NP_001318728.1	PH_PLC_plant-like	12..124	CDD:270171
		ATS1	<282..614	CDD:227511	64/342 (19%)
		FYVE	621..689	CDD:214499	8/67 (12%)
		BRX_N	869..904	CDD:372684	8/36 (22%)
		BRX	1003..1057	CDD:369842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010