DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and AT5G19420

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001190338.1	Gene:	AT5G19420 / 832062	AraportID:	AT5G19420	Length:	1139	Species:	Arabidopsis thaliana

Alignment Length:	759	Identity:	130/759 - (17%)
Similarity:	231/759 - (30%)	Gaps:	289/759 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEA-KCDALVSEISVLRQLQHPNIVQ---- 80
            |..::|:.|...|      |:|:||.|...:...|... |...||.  :.:..|..||..|
plant   519 VEVMVGSSSSSNC------SSGKLFTWGDGDKSRLGHGDKEPKLVP--TCVAALVEPNFCQVACG 575

  Fly    81 -------------------YYHHLVNREA-------------KSVYIVMECCAGGDLAQIVQRAR 113
                               .|..|.|..|             || ::....|....:|.:..|.
plant   576 HSLTVALTTSGHVYTMGSPVYGQLGNPHADGKVPTRVDGKLHKS-FVEEIACGAYHVAVLTSRT- 638

  Fly   114 SQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRD------------IKPANIFLDAAGNAK 166
                   |.|.|              .|..||.:.|.|            :|...:...|.|:
plant   639 -------EVYTW--------------GKGSNGRLGHGDADDRNSPTLVESLKDKQVKSIACGS-- 680

  Fly   167 LGDFGLARMLRR-----DQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCA----- 221
              :|..|..|.:     |||..:.      ...|...|.:::    :.:..|.:....|:
plant   681 --NFTAAVCLHKWASGMDQSMCSG------CRQPFNFKRKRH----NCYNCGLVFCHSCSNKKSL 733

  Fly   222 ---LRP----PFR--GRAFDQLSEKI-----AQGEFSRIPAI-YSTDLQEIIAFMLAVDHEQRPG 271
               :.|    |:|  .|.|::|.:.:     :....||..:: ..:|         |:|.:::
plant   734 KACMAPNPNKPYRVCDRCFNKLKKAMETDPSSHSSLSRRESVNQGSD---------AIDRDEK-- 787

  Fly   272 IEVIIRHPLVVRNISELDGKFPIL-----VDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTE 331
                    |..|:..:| .:|.:|     ||                           |.:...:
plant   788 --------LDTRSDGQL-ARFSLLEPMRQVD---------------------------SRSKKNK 816

  Fly   332 QYSFNE---------GYGQRRLSVTGVFTPDL-RSELFYSAKRKIFPAKKLQLSDPSLYESIRRE 386
            :|.||.         |..:..|::|..|.|.. .|:.|:||.   .|..::
plant   817 KYEFNSSRVSPIPSGGSHRGSLNITKSFNPTFGSSKKFFSAS---VPGSRI-------------- 864

  Fly   387 ERAEERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQN-----------IFDEVLKTRLH 440
                                  ..|....:...||.||:.|..           :.|:..::. .
plant   865 ----------------------ASRATSPISRRPSPPRSTTPTPTLSGLTTPKIVVDDTKRSN-D 906

  Fly   441 AIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPA 505
            .:..:..:|:.::|.| ||:.:||  |..::...:|::|.|....:.:..|:       ..::..
plant   907 NLSQEVVMLRSQVENL-TRKAQLQ--EVELERTTKQLKEALAIASEESARCK-------AAKEVI 961

  Fly   506 KSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAV 570
            ||      .|.:|.:.:..:...:..|:.:| |||              ::|
plant   962 KS------LTAQLKDMAERLPVGSARTVKSP-SLN--------------SFG------------- 992

  Fly   571 NPPPTGVPMQMSVSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRP 635
            :.|....|     |||......:..|...|:.::...|.|:........|..|.|..||..:.|
plant   993 SSPDYAAP-----SSNTLNRPNSRETDSDSLTTVPMFSNGTSTPVFDSGSYRQQANHAAEAINR- 1051

  Fly   636 PLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELLAAMNAAERE 679
                   |:.......|...|.|.::.:...:..|.|:....|:
plant  1052 -------ISTRSKESEPRNENEWVEQDEPGVYITLTALAGGARD 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	58/333 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	58/333 (17%)
AT5G19420	NP_001190338.1	PH_PLC_plant-like	57..164	CDD:270171
		RCC1_2	348..377	CDD:290274
		RCC1	365..413	CDD:278826
		RCC1	416..466	CDD:278826
		RCC1	470..518	CDD:278826
		RCC1	534..582	CDD:278826	12/49 (24%)
		RCC1	585..634	CDD:278826	8/49 (16%)
		RCC1	639..686	CDD:278826	12/64 (19%)
		FYVE	690..757	CDD:279674	13/76 (17%)
		Tup_N	906..956	CDD:285748	12/59 (20%)
		BRX_N	949..984	CDD:290432	6/47 (13%)
		BRX_assoc	990..1057	CDD:293233	17/92 (18%)
		BRX	1064..1118	CDD:285568	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010