DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and AT5G12350

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_568268.3	Gene:	AT5G12350 / 831110	AraportID:	AT5G12350	Length:	1075	Species:	Arabidopsis thaliana

Alignment Length:	731	Identity:	136/731 - (18%)
Similarity:	208/731 - (28%)	Gaps:	321/731 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLAVMGNGSFGTCYKVRDKSTGELFAW----KGMNYDELDEAK----CDALVSEISVLRQLQHPN 77
            |..::|:.|...|      |:|:||.|    ||.......|.|    |.|.:.|         ||
plant   481 VEVMVGSSSSSNC------SSGKLFTWGDGDKGRLGHGNKEPKLVPTCVAALVE---------PN 530

  Fly    78 IVQ-----------------------YYHHLVNREA-------------KSVYIVMECCAGGDLA 106
            ..|                       .|..|.|..|             || ::....|....:|
plant   531 FCQVACGHSLTVALTTSGHVYTMGSPVYGQLGNSHADGKTPNRVEGKLHKS-FVEEIACGAYHVA 594

  Fly   107 QIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFG 171
            .:..|.        |.|.|              .|..||.:.|.|:...|
plant   595 VLTSRT--------EVYTW--------------GKGSNGRLGHGDVDDRN--------------- 622

  Fly   172 LARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV--------------WAVGCLVYEMCA- 221
                                  ||.||:..|..:...:              ||.| :...||:
plant   623 ----------------------SPTLVESLKDKQVKSIACGTNFTAAVCIHRWASG-MDQSMCSG 664

  Fly   222 LRPPFR-----------GRAF--DQLSEK---------------IAQGEFSRIPAIYSTDLQEII 258
            .|.||.           |..|  ...|:|               :....|:::.....||...
plant   665 CRQPFSFKRKRHNCYNCGLVFCHSCTSKKSLKACMAPNPNKPYRVCDKCFNKLKKTMETDPSS-- 727

  Fly   259 AFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSG--AR--LFED-EEED 318
                               |..:.|..|...|..||  |..:.|.:...|  ||  |.|. .:.|
plant   728 -------------------HSSLSRRGSINQGSDPI--DKDDKFDSRSDGQLARFSLMESMRQVD 771

  Fly   319 GVHPELSSTMFTEQYSFN--------EGYGQR-RLSVTGVFTPDLRSELFYSAKRKIFPAKKLQL 374
            ..|.:      .::|.||        .|..|| .|::...|.|      .:.|.:|.|.|
plant   772 SRHKK------NKKYEFNSSRVSPIPSGSSQRGALNIAKSFNP------VFGASKKFFSA----- 819

  Fly   375 SDPSLYESIRREERAEERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALT------------ 427
            |.|.        .|...|.......|                   ||.||:.|
plant   820 SVPG--------SRIVSRATSPISRR-------------------PSPPRSTTPTPTLSGLATPK 857

  Fly   428 ----------QNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLL 482
                      .|:..||:|            |:.::|.| ||:.:||  |..::...:|::|.|.
plant   858 FVVDDTKRTNDNLSQEVVK------------LRSQVESL-TRKAQLQ--EVELERTTKQLKEALA 907

  Fly   483 QQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTF 547
            ...:.|..|:       ..::..||      .|.:|.:.:..:...:..|:.:|.|||:..
plant   908 ITNEETTRCK-------AAKEVIKS------LTAQLKDMAERLPVGSARTVKSPPSLNSFG---- 955

  Fly   548 KSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDS-----GDSQASSTRRKS------- 600
            .||.:...:.|.|.     ..:....|.|:...|  .||.:     |:.:|::..|..
plant   956 SSPGRIDPFNILNQ-----ANSQESEPNGITTPM--FSNGTMTPAFGNGEATNEARNEKEWVEQD 1013

  Fly   601 ----ILSLFGLSRGSK 612
                .::|..|:.|::
plant  1014 EPGVYITLTALAGGAR 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	58/346 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	58/346 (17%)
AT5G12350	NP_568268.3	PH_PLC_plant-like	19..129	CDD:270171
		RCC1_2	310..339	CDD:290274
		RCC1	327..375	CDD:278826
		RCC1	378..428	CDD:278826
		RCC1	432..480	CDD:278826
		RCC1	496..544	CDD:278826	14/56 (25%)
		RCC1	547..596	CDD:278826	8/49 (16%)
		RCC1	601..648	CDD:278826	14/97 (14%)
		FYVE	652..719	CDD:279674	13/67 (19%)
		BRX_N	911..946	CDD:290432	7/47 (15%)
		BRX	1006..1060	CDD:285568	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010