DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and NEK5

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_188722.2	Gene:	NEK5 / 821634	AraportID:	AT3G20860	Length:	416	Species:	Arabidopsis thaliana

Alignment Length:	451	Identity:	137/451 - (30%)
Similarity:	221/451 - (49%)	Gaps:	53/451 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCD-ALVSEISVLRQLQHPNIV 79
            :.||||:..:|.|:||:.:.|..||....:..|.:...:..| :|. |.:.|:|::.:|:.|.||
plant     1 MDDYEVVEQIGRGAFGSAFLVIHKSERRKYVVKKIRLAKQTE-RCKLAAIQEMSLISKLKSPYIV 64

  Fly    80 QYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            :|....|.::.  |.||...|.|||:.|:::::|......|:...|.|  ||..|:...|    |
plant    65 EYKDSWVEKDC--VCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRWMV--QLLLAIDYLH----N 121

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
            ..:||||:|.:||||......:|||||||::|.:| ..|:|.||||:||.|||:....|..|||:
plant   122 NRVLHRDLKCSNIFLTKENEVRLGDFGLAKLLGKD-DLASSMVGTPNYMCPELLADIPYGYKSDI 185

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            |::||.::|:.|.:|.|:......|..||.:...|.:|.:||:.|:.:|..||..:.|.||....
plant   186 WSLGCCMFEVAAHQPAFKAPDMAALINKINRSSLSPLPVMYSSSLKRLIKSMLRKNPEHRPTAAE 250

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGY 339
            ::|||.:...:::.....|:       |..:.|.:....:|...|:.|:..|.....:::.....
plant   251 LLRHPHLQPYLAQCQNLSPV-------FKPVVSKSEHNTNENRTGLPPKTKSAKTPIKHNQESEE 308

  Fly   340 GQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRR--------EERAE--ERQV 394
            .:::       ..|..|    |:|.|..|||..::|..|....:|.        |||||  |..:
plant   309 TEKK-------NKDTSS----SSKDKERPAKSQEMSVISTLTLLREFQKKSPKSEERAEALESLL 362

  Fly   395 ELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEE 455
            ||.....|     |:|.| ||        ..:.:...||.:.:|..||...:||:..|.::
plant   363 ELCAGLLR-----QEKFD-EL--------EGVLKPFGDETVSSRETAIWLTKSLMNVKRKQ 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	97/263 (37%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	96/262 (37%)
NEK5	NP_188722.2	STKc_Nek	3..257	CDD:270855	97/263 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I1512
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		mtm947
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960