DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and AT3G03790

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001189802.1	Gene:	AT3G03790 / 821145	AraportID:	AT3G03790	Length:	1099	Species:	Arabidopsis thaliana

Alignment Length:	776	Identity:	138/776 - (17%)
Similarity:	236/776 - (30%)	Gaps:	332/776 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 STGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGD 104
            ||||::.|.|.|                                                  |.|
plant   465 STGEVYMWDGKN--------------------------------------------------GKD 479

  Fly   105 LAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNK---IPNGTILHRDIKPANIFLDAAGNAK 166
            :|..:.|                |..|.||..|...:   :..|::.|....|.
plant   480 IAPSLSR----------------LHNLKRATTVAVGETHLLVVGSLYHPAYAPI----------- 517

  Fly   167 LGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAF 231
                    :|::.|:..|.......  :.||.:|..:|   ||.:|..|           :...:
plant   518 --------VLKKSQTLQADKCREEE--NEELDEGFMFD---DVESVNVL-----------QSVQY 558

  Fly   232 DQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGI-------------------EVIIR 277
            |...|:|       :|::.|  |.|.:|....|  |.|..|                   :::||
plant   559 DNPKERI-------VPSLKS--LCEKVAAECIV--EPRNAIQLLEIADSLGAEDLKKYCEDIVIR 612

  Fly   278 H----------------PLVVRNISEL-----------------DGKFPILVDSGEDFYTLPSGA 309
            :                |.|:.|:.:|                 ...||:::||
plant   613 NLDFILTFSPQSIANTSPDVLANLEKLLDDRSSETWSSRPLPTPTATFPVVIDS----------- 666

  Fly   310 RLFEDEEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPD-------------LRSELFYS 361
               |:||.:.   ::..|..:....|:...|.|   :.....|:             ||.:|
plant   667 ---EEEESES---DILRTRDSHVKHFSSIGGTR---MDSFLQPEDELTQHNSKEVRALRKKL--- 719

  Fly   362 AKRKIFPAKKL--QLSDPSLYESIRREERAEERQVELA-----------------EERRRKKDQE 407
            .:.:|..||:.  ||.|......::::...|...|||.                 |.:..||.::
plant   720 QQIEILEAKQSRGQLLDGQQIAKLQKKLDIESSLVELGIPVEEFPEAKATTALPLEGKANKKGKK 784

  Fly   408 QQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQLAEQRVQT 472
            ::|.:|          |.:....|.|..:.::.....|:..:::..|.::.:..:..|....:..
plant   785 KKKGNQ----------RFVQVETFPEFGEVKVEIDTMQDKEIEEICEAIKPKGGKTMLDTTMISG 839

  Fly   473 LERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPK 537
            ..::.....|.|:|..        ||..||..                        .||| .|.|
plant   840 FPKESDFVSLSQKKDN--------PPDSPRSK------------------------KLAT-AANK 871

  Fly   538 SLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPT---------GVPMQMSVSS-------- 585
            ..|....::.     |:|..::::|    ||.|.|||.         |..:...:||
plant   872 KKNRKGGLSM-----FLTGALDDVP----KPVVAPPPRPKIEGPVWGGAKISKGLSSLRDIQDEQ 927

  Fly   586 -------------NDSGDSQASSTRRKSILSLFGLSRGSKATSKSLP-----SVNQVAQAAATRV 632
                         |.|||.....:..|.:||.|       .|||.:|     |:.|......|
plant   928 SKTRSHEPVRTTKNQSGDDSPGKSEGKILLSSF-------LTSKPIPMEPAKSLQQSDVEKGT-- 983

  Fly   633 QRPPLAVKPPITQEQPAEV--PPVANLWTKEQKKQAFELLAAMNAAEREASGGGVVGSGPG 691
              ||.|     :.|.|.::  |.:.::..:|.|||     .:::.:.:..:.|..|.:|.|
plant   984 --PPWA-----SSETPRKLSRPSLRDIQMQEVKKQ-----QSLSHSPKTKTSGFTVATGQG 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	45/278 (16%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	45/278 (16%)
AT3G03790	NP_001189802.1	ANK	29..137	CDD:238125
		Ank_2	29..126	CDD:289560
		ANK repeat	29..59	CDD:293786
		ANK repeat	61..92	CDD:293786
		ANK repeat	95..126	CDD:293786
		RCC1	154..201	CDD:278826
		RCC1	205..259	CDD:278826
		RCC1	264..311	CDD:278826
		RCC1	315..365	CDD:278826
		SPOP_C_like	586..>615	CDD:269810	3/28 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010