DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and AT2G32850

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_850199.1	Gene:	AT2G32850 / 817846	AraportID:	AT2G32850	Length:	670	Species:	Arabidopsis thaliana

Alignment Length:	774	Identity:	173/774 - (22%)
Similarity:	296/774 - (38%)	Gaps:	187/774 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EESAGMD--FSQKTLQDYEVLAVMGNGSFGTCYKVRD-KSTGELFAWKGMNYDELDEAKCDALVS 65
            :|.||::  |.:......:|..|:..|.|.:.|..:| ....:.:|.|.|..:  ||...:.::.
plant    10 KEPAGLEGRFLEIGNLKVQVRNVIAEGGFSSVYLAQDVNHASKQYALKHMICN--DEESLELVMK 72

  Fly    66 EISVLRQLQ-HPNIVQYYHHLV---NREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWR 126
            |||||:.|: |||:|..|.|.:   .|..|...:.|:.| |..|..:::...:  ..|||.....
plant    73 EISVLKSLKGHPNVVTLYAHGILDMGRNKKEALLAMDFC-GKSLVDVLENRGA--GYFEEKQALT 134

  Fly   127 VLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLA----RMLRRDQSFAASFV 187
            :...:|.|:...|.:.|.  |.|||:|..|:.|.:.|..||.|||..    ::..|     |..:
plant   135 IFRDVCNAVFAMHCQSPR--IAHRDLKAENLLLSSDGQWKLCDFGSVSTNHKIFER-----AEEM 192

  Fly   188 G----------TPHYMSPE---LVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSE-KI 238
            |          ||.|.:||   |.:......|.|:||:|||::.:|..:     .|||..|: :|
plant   193 GIEEDNIRKYTTPTYRAPEMWDLFRREMISEKVDIWALGCLLFRICYFK-----NAFDGESKLQI 252

  Fly   239 AQGEFSRIPAI--YSTDLQEIIAFMLAVDHEQRPGIEVI---IRHPLVVRNISELDGKFPILVDS 298
            ..|.: |||..  ||..:.::|..||....::||.|..|   :...|.......|..:.|.:..:
plant   253 LNGNY-RIPESPKYSVFITDLIKEMLQASPDERPDITQIWFRVNEQLPANLQKSLPDRPPEMQST 316

  Fly   299 G-----EDFYTLPSGARLF-------EDEEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFT 351
            |     ....|.||.|...       ...|.|...| |.:...|:.            :.|.|.:
plant   317 GVHDGSSKSATKPSPAPRRSPPPPPPSSGESDSGGP-LGAFWATQH------------AKTSVVS 368

  Fly   352 PDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERR---RKKDQE---QQK 410
            .|          .|..|......|:.|..|.:|.:....::...:..|.|   |.||.|   .||
plant   369 ED----------NKNMPKFDEPNSNTSKSERVRVDSHQPKKPSPVRGEARGIQRNKDLETTISQK 423

  Fly   411 RDQELLKEAPSSPRALTQNIFDEVLKT-----------------RLHAIRAQESLLQQKLEELQT 458
                  ...|::...:|:...|:...:                 :..|:.|:...|:.:|::.::
plant   424 ------NTTPAAANNMTRVSKDDAFNSFVADFDTTKFDNGNKPGKEEALEAEIQRLKDELKQTKS 482

  Fly   459 REQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSP 523
            .:.|:....:::..:.|..::: ||..|.|.:.:.  |.|.|.|..::            |:.||
plant   483 EKAEITAKFEKLSAICRSQRQE-LQDLKQTLASKS--ASPSPSRDSSQ------------NQPSP 532

  Fly   524 TVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDS 588
                 .:.::.:..|.:.:....::..|....:                         |..|:|:
plant   533 -----GMHSMSSTPSRDKMEGTMWELQQDRSNW-------------------------STGSSDT 567

  Fly   589 GDSQASSTRRKSILSLFGLSRGSKAT-SKSLPSVNQVAQAAATRVQRPPLAVKPPITQEQPAEVP 652
            ...|..|...|.::.  ..|:|:..| ::|:.:.::.|.||.|:...|
plant   568 NSWQPFSDEAKPVME--SASKGNNNTINQSVRTRSKPASAAGTQGFEP----------------- 613

  Fly   653 PVANLWTKEQKKQAFELLAAMNAAEREASG-GGVVGSGPGGARRQHLRQSVRERNSTLQ 710
                 |..|  .::|. .||.:||...||| ...:|||...::| :....:||...|.|
plant   614 -----WGFE--TESFR-AAATSAAATSASGTQRSMGSGNSTSQR-YGNSKMRENQKTAQ 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	84/290 (29%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	84/289 (29%)
AT2G32850	NP_850199.1	STKc_GAK_like	26..299	CDD:270887	84/290 (29%)
AT2G32850	NP_850199.1	Macoilin	<261..>559	CDD:370635	61/346 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910