Protein Alignment Nek2 and NEK11

DIOPT Version :9

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001308150.1
• Gene: NEK11 / 79858
• HGNCID: 18593
• Length: 687
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 150/609 - (24%)
• Similarity: 241/609 - (39%)
• Gaps: 162/609 - (26%)

  Fly     1 MSGEESAGMDFSQKTL--QDYEVLAVMGNGSFGTCYKVRDKST---GELFAWKGMNYDELDEAKC 60
            :||  |..:....|||  :.|.:...:|:|||||.|.|.||..   .||...|.::..||:..:.
Human    11 VSG--STAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNET 73

  Fly    61 DALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECC------------------------- 100
            .....|..:|.:|.||.||:::...|  |..:..|:.|.|
Human    74 VQANLEAQLLSKLDHPAIVKFHASFV--EQDNFCIITEYCEDLSKENCKPLLNEIKEDTNKWKNI 136

  Fly   101 -----------------AGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTIL 148
                             .|.||...:|..:...:.|.|..|.....||...:...|.:    .||
Human   137 PCSWVGRINIVKMAILPKGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER----RIL 197

  Fly   149 HRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAV 212
            |||:|..|:||  ..| .|:||||::|:|......|.:..|||||||||.:|.:.||.|||:|::
Human   198 HRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSL 260

  Fly   213 GCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIR 277
            .|::||||.:...|.|..|..:..||.:|:...:|..|..:|..|:..||..:...||....|::
Human   261 ACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 325

  Fly   278 HPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGYGQR 342
            .|.:...:..|..::..:....::.           |.:::..|  :.:.|            |:
Human   326 IPYLDEQLQNLMCRYSEMTLEDKNL-----------DCQKEAAH--IINAM------------QK 365

  Fly   343 RLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERRRK---- 403
            |:.:     ..||:   .|..:|:.|.::::|                 |:::.|:|:.||
Human   366 RIHL-----QTLRA---LSEVQKMTPRERMRL-----------------RKLQAADEKARKLKKI 405

  Fly   404 ---KDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQL 465
               |.:|..||.|||....       .|.:..:||..:.| ::..|...:|....|....|:..
Human   406 VEEKYEENSKRMQELRSRN-------FQQLSVDVLHEKTH-LKGMEEKEEQPEGRLSCSPQDED- 461

  Fly   466 AEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIP-----------------------PRKP--A 505
             |:|.|..|.:..|..|:        ..|.:.|||                       |..|  |
Human   462 -EERWQGREEESDEPTLE--------NLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVA 517

  Fly   506 KSHHD---DTYCTIELNETSPTVA 526
            :.::.   |:||. |.:|....:|
Human   518 EEYYADAFDSYCE-ESDEEEEEIA 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	93/308 (30%)
		S_TKc	19..281	CDD:214567	93/307 (30%)
NEK11	NP_001308150.1	STKc_Nek11	28..329	CDD:270861	93/308 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43671
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020