DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and HECTD3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_078878.3	Gene:	HECTD3 / 79654	HGNCID:	26117	Length:	861	Species:	Homo sapiens

Alignment Length:	523	Identity:	105/523 - (20%)
Similarity:	181/523 - (34%)	Gaps:	158/523 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LFAWKGMNYDELDEAKCD-ALVSEISVLRQLQ-HPNIVQYYHHLVNREAKSVYIVMECCAGG-DL 105
            ::..:|.|..:|.:...| .|:.::.||..:. |..|::..             ::||...| |:
Human   312 VYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIR-------------IVECRDDGIDV 363

  Fly   106 AQIVQRARSQRQR--------FEEPYIWR----------VLFQLCRALQ--------VCHNKIPN 144
            .....:.:|.|||        |:...:.|          ||::....||        |.|:.:|.
Human   364 RLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPA 428

  Fly   145 -----GTILHRDIKPANIFLDAAGNAKLGDFGL-ARMLRRDQSFAASFVGTPHYMSPELVKGRKY 203
                 ||.  .:||....||..:....    || |:.||..:|...||:       |.|...|:.
Human   429 WDHTLGTF--SEIKQVKQFLLLSRQRP----GLVAQCLRDSESSKPSFM-------PRLYINRRL 480

  Fly   204 DRKSDVWAVGCLVYEMCALR-PPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQ-------EIIA- 259
                      .:.:..|..| |..:...|.|:.|.:...:....|..|...::       :.||
Human   481 ----------AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAE 535

  Fly   260 -----------FMLAVDHEQRP-GIEVIIRHPLVVRNISELDGKFPILVDSGE--DFYTLPSGAR 310
                       .:..:..|..| ..:..:..|..||..::.:|       :||  |.|......|
Human   536 GIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNG-------TGEARDMYVPNPSCR 593

  Fly   311 LFEDEEEDG--------------------VHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLR 355
            .|...|..|                    |..:||.    |:.|:::.:.    :|..|....|
Human   594 DFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSG----EEVSWSKDFP----AVDSVLVKLL- 649

  Fly   356 SELFYSAKRKIFP---AKKLQ----LSDPSLYESI--------RREERAEERQVELAEERRRKKD 405
             |:.....::.|.   .|:|.    |||..:.|.|        ...:|:  |.::|.::.|.::.
Human   650 -EVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRS--RFIQLVQKARLEES 711

  Fly   406 QEQQKRDQE-LLKEAPSSPRALTQNIFDEVLKTRLH-AIRAQESLLQQKLEELQTREQELQLAEQ 468
            :||....|. |||..|       |.:.|.:....|. .:.....:....|.:| ||.::.:.::.
Human   712 KEQVAAMQAGLLKVVP-------QAVLDLLTWQELEKKVCGDPEVTVDALRKL-TRFEDFEPSDS 768

  Fly   469 RVQ 471
            |||
Human   769 RVQ 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	56/292 (19%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	56/292 (19%)
HECTD3	NP_078878.3	APC10-HECTD3	238..371	CDD:176487	13/71 (18%)
HECTD3	NP_078878.3	HECT	579..845	CDD:366212	46/213 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010