DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc5.2

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	472	Identity:	84/472 - (17%)
Similarity:	158/472 - (33%)	Gaps:	164/472 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSE-ISVLRQLQHPNIVQYYHHLV 86
            ||..||||     ::.....:.|...|.::.:|.:.  :.::|| :.|::|...|::.....|
Zfish   399 AVCLNGSF-----LKPSLDEQDFDLVGKSFSKLTDN--EKVISEVVKVIQQTLLPSLNPKPAH-- 454

  Fly    87 NREAKSVYIVMECCAGGDLAQIVQRARS-QRQRFEEPYIWRVLFQLCRA----LQVCHNKIPNG- 145
             .|:..:|::        |.::::.... ||....:....::| ||..|    |::..:|:|:.
Zfish   455 -EESLRLYLL--------LPELIKGLEQYQRSELNKALASKIL-QLNSAAREMLEMFWSKLPDDW 509

  Fly   146 -----TILHRDIKPANIFLDAAGNAKLGDF--------------GLARMLRRDQSFAASFVGTPH 191
                 .:.|::            :|.|.|:              .|.|:|:.......|
Zfish   510 LKSLVKLFHKE------------SADLIDYMSVCAMDSDLKHLQNLLRILQMAYKVCCS------ 556

  Fly   192 YMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSE---KIAQGEFSRIPAIYSTD 253
                         ...|:.....::||:..|....:. ..|.|::   .:......::...:...
Zfish   557 -------------THRDITISDFIIYEISDLLNALQA-TIDDLADWDPFVDYVYMMKLRDYFIKT 607

  Fly   254 LQEIIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKF--------------PILVDS------ 298
            |:.::.|....|:..:.|   |..| |.::.|.....:|              .:|:|:
Zfish   608 LEILVKFPFVADYASKRG---IFNH-LEIKMIRRSSNRFLGNATFNVLHINRESLLMDTLKYLRQ 668

  Fly   299 --------------GED----------FYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGY 339
                          |||          |::|.|.:.|..|::...|||  ||.::     ||..:
Zfish   669 NTHSFSHLSRVAFIGEDGIDMRGLSAEFFSLISKSFLKWDKKILEVHP--SSLVW-----FNPHH 726

  Fly   340 --GQRRLSVTGV-----------FTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEE 391
              |.:.....||           ...|....||          |||....|||      ::..|.
Zfish   727 TRGNKNFYYLGVICGMALYNRHHINIDFPLALF----------KKLLQQKPSL------DDLEEL 775

  Fly   392 RQVELAEERRRKKDQEQ 408
            ..||....:...|:.|:
Zfish   776 SPVEARSLKNLLKEDEE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	47/286 (16%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	47/286 (16%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274
		RCC1	136..186	CDD:278826
		RCC1	189..238	CDD:278826
		RCC1	242..290	CDD:278826
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058	34/167 (20%)
		HECTc	678..984	CDD:214523	32/138 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010