Protein Alignment Nek2 and nek4

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001072768.1
• Gene: nek4 / 780225
• XenbaseID: XB-GENE-5914376
• Length: 791
• Species: Xenopus tropicalis
• Alignment Length: 987
• Identity: 187/987 - (18%)
• Similarity: 325/987 - (32%)
• Gaps: 286/987 - (28%)

  Fly    32 HERIDSLIYGYLRRNGMNQAADAMEQESPFLGESLSRFDHNNRPIVVLNDRLHDH---TLEDIIT 93
            |||  ||....::|..  |:...:..|...|....|.|:|:.    .|::::.:.   .||.:.|
 Frog   125 HER--SLRMTVVKRQA--QSPSGVSSEVEVLKALKSLFEHHK----ALDEKVRERLRAALERVTT 181

  Fly    94 IFN------------------RDGRFGVNKSMVEFG------------EDLRRL----------- 117
            :..                  |||. ...:..||.|            |:|:.|
 Frog   182 LEEQLAGAHQQVSALQQGAGVRDGA-AEEEGTVELGPKRLWKEDTGRVEELQELLEKQNFELSQA 245

  Fly   118 TNRFITITSTPA---------------SSGRSTSHQQLYGRSAYSRHKQSQQYSTIRAPQAIAHM 167
            ..|.:|:|:|..               |...|:.||:....:...:....::.:|:......|..
 Frog   246 RERLVTLTTTVTELEEDLGTARRDLIKSEELSSKHQRDLREALAQKEDMEERITTLEKRYLAAQR 310

  Fly   168 ELQRVNQ----------NADARYRE-EQQFLPRVNVLSVAP-------APTSSVPVIHQQLHQAS 214
            |...::.          |.::.:|: |::......:|.||.       ....::|.:..:|.|..
 Frog   311 EATSIHDLNDKLENELANKESLHRQCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELAQRI 375

  Fly   215 PAIQKDNVPDEPVNSQGSQITSGDLQHQFEEDSQKTSRRKINNPQNLNAKVENALNPLVGYINEH 279
            .|:.|.......:.....|: .|.|:.:.:|.::...|.|:|  ::.|.::.:.::.|:...||
 Frog   376 AALTKAEERHGNIEEHLRQL-EGQLEEKNQELARVRQREKMN--EDHNKRLSDTVDRLLSESNE- 436

  Fly   280 EGIADIDFNTEFSLEGINAEFIRALDYD----PEREMMQDQQDDQPFNEFFGEVLENREPHLTNA 340
                    ..:..|:    |.:.||:..    .|.|..|.|.::|..::  |.:.|..|.
 Frog   437 --------RLQLHLK----ERMAALEEKNTLIQELESSQRQIEEQHHHK--GRLSEEIEK----- 482

  Fly   341 SIIVQEEVVVETEEGLVEDGEIEASNRIVYSGVPEPLLSPIPKDLSFRMQPGTT---PGRVGQPV 402
              :.||...::...|...||        |:|      .|.:......|...|||   |..|.:..
 Frog   483 --LRQEVDQLKGRGGPFVDG--------VHS------RSHMGSAADVRFSLGTTTHAPPGVHRRY 531

  Fly   403 QPMKPDNAIPKKAAPVP------------FEPKLEDRER-----------IIRRSGGRSQSRSLR 444
            ..::.::|...:.:|:|            .:|::.|.:.           ::..| |.|.:::|.
 Frog   532 SALREESAKDWETSPLPGMLAPAAGPAFDSDPEISDVDEDEPGGLVGSADVVSPS-GHSDAQTLA 595

  Fly   445 YGSSPQQSRPVEEQKRHRDTEKERERDHEKRTDRDRDREKRKDKHESDVTSHPTITRHRRYSEAH 509
            . ...:|...:.|:.|....|||             ..|.|.::.|:.|||......:.:.....
 Frog   596 M-MLQEQLDAINEEIRMIQEEKE-------------STELRAEEIETRVTSGSMEALNLKQLRKR 646

  Fly   510 HSTNVQSDRESISSTS---SRSNAPEKRERDAEKERKRKD--------KEHRRAL-----EADNN 558
            .|........|::|.|   |..:.|:...|.|.::..|..        ::|||.|     ..:|.
 Frog   647 GSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENR 711

  Fly   559 KYHAREKEKQKQPSFHQKSNEQQTSEIPVIIRTTQVG--------GSDKPKDPRKQPIGSPSSAK 615
            :..|..|.:...||            .|..:|..::|        |....:|....|..|.||..
 Frog   712 EDKATIKCETSPPS------------SPRTLRLEKLGHPALSQEEGKSALEDQGSNPSSSNSSQD 764

  Fly   616 RKHDDVARREFK------IPKKHSSSSKPDSRYGSSSHP--KESSAMQSKPYKSSYTKSQADQEL 672
            ..|....|:..|      ..||........||.|::.|.  .:|.....:|...:...:||::
 Frog   765 SLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDGATGHVLLTDSEFSMQEPMVPAKLGTQAEK-- 827

  Fly   673 CDGDDRKDSTHFL--------NPVGHLARSSVSS---LLVNCDTTYQQFHDDLQEKISKSRRSAN 726
               |.|....|.|        .|.......:|.|   |.|.....|          ::..|.:..
 Frog   828 ---DRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWY----------VAACRANVK 879

  Fly   727 LPSLSPANSEEYSHNNIPVNN--HPKGQSFAPRKGALLSAKPKLSPTS----------------- 772
            ..::..|.|:......|.::|  |......|.::...|:: |...|||
 Frog   880 SGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTS-PSAPPTSRTSSGNVWVTHEEMETL 943

  Fly   773 -SSHSTDPESSSCASS-----------DNE---TSDATSQRSV-------ARSPDAKKTRLSSLD 815
             :|..||.|..|.|.:           .||   :......||.       ||..|    .|:..|
 Frog   944 ETSTKTDSEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLD----HLTKKD 1004

  Fly   816 LSKAEKMLDRIH 827
            |....||:|..|
 Frog  1005 LRVHLKMVDSFH 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	58/325 (18%)
nek4	NP_001072768.1	STKc_Nek4	9..265	CDD:270862	29/148 (20%)