DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and hectd3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001072497.1	Gene:	hectd3 / 779952	XenbaseID:	XB-GENE-5937967	Length:	845	Species:	Xenopus tropicalis

Alignment Length:	304	Identity:	58/304 - (19%)
Similarity:	103/304 - (33%)	Gaps:	82/304 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 IPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRH----------PLVVRNISELDGKFPI------ 294
            :|.:|       |...:||:|...|.::...:.          .|..::...||.::|:
Frog   455 MPCLY-------INRRIAVEHRDNPSLDPSYKKTVFSQVYEGLKLTDKSEKPLDYRWPVRYEQWW 512

  Fly   295 --------LVDSGEDFYTLPSGARLFEDEEEDGVHPEL--SSTMFTEQYSF-----NEGYGQRRL 344
                    ::|.|..          |.|...| :..||  ||........|     |:|.|....
Frog   513 ECKFIAEGIIDQGGG----------FRDSLAD-ISEELCPSSADIPVPLPFFVRTSNQGNGTGEA 566

  Fly   345 SVTGVFTPDLR--------SELFYSAKR-KIFPAKKLQLSDPSL-YESIRREERAEERQVELAEE 399
            ....|..|..:        .:|..:|.| |.|    |.|:.|.| ::.:..||.:..:.....:.
Frog   567 QDMYVPNPSCKDLAKYEWIGQLMGAALRGKEF----LVLALPGLVWKQLTGEEVSWSKDFPAVDS 627

  Fly   400 RRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDE--------------VLKTRLHAIRAQESLLQ 450
            ...|..:..:..|:|..:...|.....|..:.|:              :.|.|:..||..:   :
Frog   628 LLVKLLEMMELMDEETFEFKFSGELTYTTVLSDQKMVELVPGGSNISVLYKDRVEFIRMVQ---K 689

  Fly   451 QKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQP 494
            .:|||  ::||...|....::.:.:.:.:.|..||.....|..|
Frog   690 ARLEE--SKEQIGALQAGLLKVVPQAVLDLLTWQELEKRVCGDP 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	7/44 (16%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	7/44 (16%)
hectd3	NP_001072497.1	APC10-HECTD3	222..355	CDD:176487
hectd3	NP_001072497.1	HECTc	512..837	CDD:421431	47/240 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010