Protein Alignment Nek2 and nek11

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001072436.1
• Gene: nek11 / 779890
• XenbaseID: XB-GENE-955651
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 153/605 - (25%)
• Similarity: 241/605 - (39%)
• Gaps: 135/605 - (22%)

  Fly    25 MGNGSFGTCYKVRDKS---------------TGELFAWKGMNYDELDEAKCDALVSEISVLRQLQ 74
            :|.|||||.|.|.||.               .|||      |.:|..:|..:|     .:|.:|.
 Frog    34 LGKGSFGTVYLVIDKKAKDEQESLKVLKEIPVGEL------NPNETVQANVEA-----QLLSKLD 87

  Fly    75 HPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCH 139
            ||.||:::...:..|  |..|:.|.|.|.||...|:..:...::..|..:.....||...:...|
 Frog    88 HPAIVKFHASFLENE--SFCIITEYCEGRDLDFKVRECKKNEEKIAENQVVEWFIQLLLGVNYMH 150

  Fly   140 NKIPNGTILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKY 203
            .:    .|||||:|..||||  ..| .|:||||::|:|......|.:|.|||:|||||.:|.:.|
 Frog   151 VR----RILHRDLKAKNIFL--KNNLLKIGDFGVSRLLMGSCDLATTFTGTPYYMSPEALKHQGY 209

  Fly   204 DRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQ 268
            |.|||:|::||:::|||.|...|.|..|..:...|.:||...:|..||:.|..|:..||..|...
 Frog   210 DSKSDIWSLGCILHEMCCLEHAFIGYNFLSVVISIVEGETPSLPDCYSSSLNLIMNRMLNKDPAL 274

  Fly   269 RPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQY 333
            ||....|::.|.:...:.::  |:.:.....:|..|:..       :|.|.:...:......:..
 Frog   275 RPSAGEILQDPFINEQLKQV--KWEVYGAEVKDKTTICK-------KEADQIRNVVQRKFHLQTL 330

  Fly   334 SFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRR-----EERAEERQ 393
                    |.||.....||..|..|           :||..:|    |..||     ||:.:|..
 Frog   331 --------RELSEVQKMTPRERMRL-----------RKLNAAD----EKARRLKQLAEEKYQENH 372

  Fly   394 VELAEERRRK--------KDQEQQKRDQELLKEAPSSPRALTQNIFD---EVLKTRLHAIRAQES 447
            ..:.|.|.|.        ...:|......|::..|.|.|..|...::   |.::.||.|......
 Frog   373 KRMQELRSRNFQLHSIDVLHVQQDDTSNHLIQSEPMSARHYTPQSYEDESEDIQDRLCASEPSRE 437

  Fly   448 L-----------------LQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCS----- 490
            :                 ..::.:|....|.|.....|.....:..::..:|..|....|
 Frog   438 IPEDPCVADAYYEDGFDSCSEESDECVEEEDEYDSGSQITYQQDSDVKAMVLHLEDVLASSCFDT 502

  Fly   491 -CRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTF------- 547
             ....::||||.|..|            :|:   |:|:..|..: ...::.::.|.:|
 Frog   503 DAATNMSPPIPLRSRA------------IND---TMAQTKLKRM-RESAVQSMGKKSFDKVYSYL 551

  Fly   548 ------KSPQKFVTYGIENM 561
                  |:.:|.|...:|:|
 Frog   552 KSARQNKTSEKEVKKQLESM 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/271 (35%)
nek11	NP_001072436.1	STKc_Nek11	27..287	CDD:270861	95/271 (35%)