DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and rpgr

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_031752069.1	Gene:	rpgr / 733454	XenbaseID:	XB-GENE-982274	Length:	1225	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	133/711 - (18%)
Similarity:	223/711 - (31%)	Gaps:	252/711 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SFGTC-YKVRDKST-----------GELFAW-----------KGMNY---DELDEAKCDALVSEI 67
            ||.|. ||::..|.           |:||.|           ||..|   .::|..|..|.:|
Frog   136 SFFTAQYKIKQLSAGSNMSAALTVDGKLFMWGDNSEGQLGLEKGTIYCTPQKVDTGKPIAWIS-- 198

  Fly    68 SVLRQLQHPNIVQYYHHLVNREAKSVY--------------------------------IVMECC 100
                       ..|||.....:...:|                                :.|..|
Frog   199 -----------CGYYHSAFVTQDGELYTFGEPENGKLGLPPDKIKKHKKPQRVLGLSGKVTMVSC 252

  Fly   101 AGGDLAQIVQRARSQRQRFEEPYIWRV--LFQLCRALQVCHNKIPNGTIL--------------H 149
            .|.....:.::         |.|.:.:  ..||.....:....||.....              |
Frog   253 GGEHTIAVTEK---------EVYTFGLGQFGQLGHGTFIFETHIPKAVDALTKKKIRYVTCGENH 308

  Fly   150 RDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGC 214
            ..|......|...|:.:.|..||.     :::|...||  |...|..|    |:..:| |...||
Frog   309 TAIITEKGLLYTFGDGRHGKLGLG-----EENFTNQFV--PILCSNFL----KFTVQS-VACGGC 361

  Fly   215 LVYEMCALRPPFRGRAFDQLSEKIAQGEFSR----IPAI-----YSTDLQEIIAFML-----AVD 265
            .:......||        |.||.|...|...    :|::     .||.||...:..|     ...
Frog   362 HMLVFATPRP--------QESEVIINDELKENLLVVPSLNGDSEMSTSLQRSHSARLRRREKETS 418

  Fly   266 HEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFE-DEEEDGVHPELS---- 325
            .||..|:...: .||  ||.| |:..|  |..|    .|:|:  ||.: .|...|.:.|..
Frog   419 PEQFRGLNRTL-PPL--RNHS-LNSSF--LASS----KTVPT--RLLQVSESNSGSYKETHLQDL 471

  Fly   326 -------------------STMFTEQYSFNEGYGQRRLSVTGVFTPDL-------------RSEL 358
                               |...|:..:..||||.         |||:             ::..
Frog   472 TPNSKPDAADNGENLVQSFSAHDTDSDNQPEGYGN---------TPDVLNMTHAMSLNPANKTLS 527

  Fly   359 FYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERRRKKD-------QEQQKRDQELL 416
            |...:::....|.::|......::::. .::..:|:.|...:.:..|       |..|....::.
Frog   528 FSPVQKRKKNTKNVKLKYDGKVDTVQM-NKSRSQQLSLMSSKSQSSDGGDSSAGQNSQYSSADVT 591

  Fly   417 KEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKL 481
            :|.|         |..:::|.:.|  :|:|:   .||:...::||    .:..|.:.|.|:....
Frog   592 EELP---------IALKIIKEKFH--KARET---SKLKFFSSQEQ----MQTDVPSSEHQLMASN 638

  Fly   482 LQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVT 546
            |..:::.   ||..: .|..|:...|.|.:..|...|                  :..|..:.:.
Frog   639 LSDKRYE---RQSDS-TITERQKQHSKHPNMICVKNL------------------EGKNGQKTLK 681

  Fly   547 FKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDSGDSQASSTRRKSILSLFGL 607
            |.:...||:           |..::...:.:     |||.|..||:...:.:|...:|..:
Frog   682 FSAKGSFVS-----------KAEISSSSSSL-----VSSADMSDSRIKRSHKKQHANLHSI 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	65/339 (19%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	65/339 (19%)
rpgr	XP_031752069.1	ATS1	<42..334	CDD:227511	37/224 (17%)
rpgr	XP_031752069.1	RCC1	315..362	CDD:395335	15/58 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010