DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and Nek2l1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_345901.5	Gene:	Nek2l1 / 690209	RGDID:	1582899	Length:	443	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	176/502 - (35%)
Similarity:	254/502 - (50%)	Gaps:	102/502 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::|||||..:|.||:|.|.|:|.||.|::..||.::|..:.|.:...||||:::||:|:|||||:
  Rat     5 VEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVR 69

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            ||..:::|...::|||||.|.|||||.::.:....||..||.::.||:.||..||:.||.:...|
  Rat    70 YYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGG 134

  Fly   146 -TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             |:||||:||||:|||:..|.|||||||||:|..|.|||.:|||||:|||||.:....|:.|||:
  Rat   135 HTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQISRLSYNEKSDI 199

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQ--LSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGI 272
            |::|||:||:|||.|||  .||:|  |:.||.:|.|.|||..||..|.::|..||.:....||.:
  Rat   200 WSLGCLLYELCALMPPF--TAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSV 262

  Fly   273 EVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNE 337
            |.|:..||:...::|                                           ||
  Rat   263 EEILESPLIADLVAE-------------------------------------------EQ----- 279

  Fly   338 GYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYE-------------SIR-REER 388
               :|.|...|               |:.....|||.|.|.|.|             ::| ||:.
  Rat   280 ---RRNLERRG---------------RRSGEPSKLQDSSPVLSELKLKERQLQDRERALRAREDS 326

  Fly   389 AEERQVELAEERRRKKDQ----EQQKRDQELLKE-------------APSSPRALTQNIFDEVLK 436
            .|:::.||....|..:|:    |...::..||||             .|||......:...|..:
  Rat   327 LEQKERELCIRERLAEDKLARAESLLKNYSLLKEHRLLCLAGGSELDLPSSALKKKVHFHGESKE 391

  Fly   437 TRLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQ 483
            ....:..::..|.:.|..:|:.|....||..|.:..:|:..|.|..|
  Rat   392 NTTRSENSESQLAKSKCRDLKKRLHAAQLCAQALSDIEKNYQLKSRQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	133/265 (50%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	132/264 (50%)
Nek2l1	XP_345901.5	STKc_Nek2	7..271	CDD:270857	133/265 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		oto98687
orthoMCL	1	0.900	-	-		OOG6_104455
Panther	1	1.100	-	-	LDO	PTHR43671
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4876
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920