DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and Nek5

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_008769592.1	Gene:	Nek5 / 685440	RGDID:	1593817	Length:	677	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	132/483 - (27%)
Similarity:	214/483 - (44%)	Gaps:	109/483 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :..::::.::|.|:||..|..:|||.......|.::..:..||.    .:|:::|.:::|.|||.
  Rat     1 MDKFDLIKIIGEGTFGKVYLAKDKSESCHCVIKEISLTKEKEAS----KNEVTLLAKMKHSNIVT 61

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR---FEEPYIWRVLFQLCRALQVCHNKI 142
            ::...  :|...::||||.|.||||.:     |.||||   |.|..|.....|:...|:..|:|
  Rat    62 FFSSF--QENSRLFIVMEYCDGGDLME-----RIQRQRGVLFSEDQILCWFVQISLGLKHIHDK- 118

  Fly   143 PNGTILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRK 206
               .:||||||..||||...|. |||||||.||.|......|.:..|||:|:|||:.:.|.|:.|
  Rat   119 ---KVLHRDIKSQNIFLSKNGMVAKLGDFGTARTLNNSMELAQTCAGTPYYLSPEICQNRPYNNK 180

  Fly   207 SDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPG 271
            :|:|::||::||:|.|:.||.......|..||.||..:.|...:|.|||.:|..:..|..:.||.
  Rat   181 TDIWSLGCVLYELCTLKHPFESDNLHHLVLKICQGRVAPISPHFSLDLQSLIPQLFRVSPQDRPS 245

  Fly   272 IEVIIRHP----LVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQ 332
            |..:::.|    ||.|.:|                                   ||:.|...
  Rat   246 INSLLKRPFLETLVARYLS-----------------------------------PEIHSRRI--- 272

  Fly   333 YSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELA 397
                :.:.:...:..| ||...|.                     |.:.:...:.::|.||.:|.
  Rat   273 ----QSHARMENAAVG-FTACWRG---------------------SPWSAAYLQRKSEARQYKLK 311

  Fly   398 EERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRA---QESLLQQKLEELQTR 459
            .||:.          |:|:.......:::.|.:       |..::.|   :...||...||  |:
  Rat   312 VERQL----------QDLVYSYDGPVQSMAQGL-------RPSSVEAHPNERENLQSHREE--TK 357

  Fly   460 EQELQLAEQRVQTLERQMQEKLLQQEKH 487
            .|||:..:.::...|...|.:.::|:.|
  Rat   358 FQELRYRKNKMNDQEYWKQLEEIRQQYH 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	97/270 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	97/269 (36%)
Nek5	XP_008769592.1	PKc_like	3..255	CDD:304357	97/266 (36%)
Nek5	XP_008769592.1	S_TKc	4..255	CDD:214567	97/265 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920