Protein Alignment Nek2 and NEK4

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_016862574.1
• Gene: NEK4 / 6787
• HGNCID: 11399
• Length: 870
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 202/812 - (24%)
• Similarity: 321/812 - (39%)
• Gaps: 188/812 - (23%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            |..|..|.|:|.||:|....|:.:..|:.:..|.:|.......:..|...|..:|.||:|||||.
Human     3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVT 67

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            |.......:. .:||||..|.||||.:.::..:.|.....:...|.|  |:..|||..|.|
Human    68 YKESWEGGDG-LLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFV--QIAMALQYLHEK---- 125

  Fly   146 TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVW 210
            .|||||:|..|:||......|:||.|:||:|......|::.:|||:||||||...:.|:.|||||
Human   126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVW 190

  Fly   211 AVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVI 275
            |:||.||||..|:..|..:..:.|..:|.:|:...:|..||.:|.|:|..||:...|:||.:..|
Human   191 ALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSI 255

  Fly   276 IRHPLVVRNISELDGKFPIL-----VDSGED----FYTLPSGARLFEDEEEDGVHPELSSTMFTE 331
            :|.|.:.|.||.......|.     :.:|:.    |.|:.||.   .:...:.:||:..|:..::
Human   256 LRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGE---AESNHEVIHPQPLSSEGSQ 317

  Fly   332 QYSFNEG--YGQRRLSVTGVF-TP----------DL--RSEL--FYSAKRKIFPAK-KLQLSDPS 378
            .|...||  ..|.:...:|:. :|          ||  .:||  ..|....|.||| :..:||..
Human   318 TYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGF 382

  Fly   379 LYESIRREERAEER----------QVELAEERRRKKDQ--------------------------- 406
            :.|:..|...|...          :.|:.::..:...|
Human   383 VQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPL 447

  Fly   407 --EQQKRDQELLKE----------APSSPRALTQNIFDEVLKTRLHAI-----RAQESLLQQKLE 454
              ||:.:||.|...          |.|:.|.|..: ......:|:..|     .||:.:..:.:.
Human   448 IKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSS-DSPASASRVAGITGVCHHAQDQVAGECII 511

  Fly   455 ELQTR-EQELQLAEQRVQ-TLERQMQEKLLQQEKHTCSCRQ--------PIAPP--IPPRKPAKS 507
            |.|.| ..:||......: :|.||.::|..:|.:|....||        ..:||  :|      |
Human   512 EKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLP------S 570

  Fly   508 HHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNP 572
            |              |.|.|:::.:  ..|.....|:|.
Human   571 H--------------PIVGKVDVTS--TQKEAENQRRVV-------------------------- 593

  Fly   573 PPTGVPMQMSVSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPL 637
              ||     ||||:.|.:..:|..|..|......|.:..:..|.|.|||.:.:.:.|
Human   594 --TG-----SVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVA-------- 643

  Fly   638 AVKPPITQEQPAEVPPVANLWTKEQKKQAFELLAAMNAAEREAS---GGGVVGSGPGGARRQHLR 699
            ....|..::||.....:::..:..|:::....|:....:...:|   ..|..|.|.|
Human   644 GPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKG-------- 700

  Fly   700 QSVRERNSTLQRNRMRRSLVVATGHQKLTTRD 731
                      |.|.:...:.:.|...||.:::
Human   701 ----------QTNEINALVQLMTQTLKLDSKE 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/262 (37%)
NEK4	XP_016862574.1	STKc_Nek4	5..261	CDD:270862	98/262 (37%)