Protein Alignment Nek2 and Nek10

DIOPT Version :9

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001381921.1
• Gene: Nek10 / 674895
• MGIID: 2685128
• Length: 1126
• Species: Mus musculus
• Alignment Length: 622
• Identity: 164/622 - (26%)
• Similarity: 269/622 - (43%)
• Gaps: 105/622 - (16%)

  Fly    14 KTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNY-------DELD-EAKCDALVSEISVL 70
            |.:.||.||..:|:|:||..||||.:|...|.|.|.:|.       |:.| ::....:|||::::
Mouse   514 KYIGDYAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTII 578

  Fly    71 R-QLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRA 134
            : ||.|||:|:||...:  |...:|||||...|..|.:.....:.:...|.|..:|::..|||.|
Mouse   579 KEQLYHPNVVRYYKTFL--ENDRLYIVMELIEGAPLGEHFNSLKEKHHHFSEERLWKIFIQLCLA 641

  Fly   135 LQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVK 199
            |:..|.:   ..|:|||:.|.||.|.......:.|||||:. :::.|...|.|||..|..||::|
Mouse   642 LRYLHKE---KRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQ-KQESSKLTSMVGTILYSCPEVLK 702

  Fly   200 GRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIP-AIYSTDLQEIIAFMLA 263
            ...|..|:||||.||::|:|..|.|||.......|:.||.:..:..:| .|||..:.:.|...|.
Mouse   703 SEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLT 767

  Fly   264 VDHEQRPGI--------EVIIRH-------PLVVRNISELDGKFPILVDSGEDFYTLPSGARLFE 313
            .|.|.||.|        :|::::       .|.:....|.:.:               ...|.|.
Mouse   768 PDAEARPDIVEVSSMISDVMMKYLDRLSTSQLALERKLERERR---------------RTQRYFM 817

  Fly   314 DEEEDGV--HPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQL-- 374
            :...:.|  |.||:   ...|.:|.:.    .||.:......|:|||..||:   .|.:...:
Mouse   818 EANRNAVTCHHELA---LLSQETFEKA----SLSSSSSGAASLKSELSESAE---LPGEGCHIPC 872

  Fly   375 --SDPSLYESIRREERAEERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKT 437
              .:..:.|.:..|:..:...||  ::...:.|.|....|.  ...:.|||  |.::.| .:||.
Mouse   873 GKEEDRVCEEVLSEDNFQLESVE--KDLYSELDDELDVSDN--CSSSSSSP--LKESTF-SILKR 930

  Fly   438 RLHAI-RAQESLLQQKLEELQTREQE---------------LQLAEQRVQTLERQMQEKLLQQEK 486
            ...|. |.:.|..:..:..|.:|.:.               :.:::::|:.:...:|:.|:|..|
Mouse   931 SFSASGRERHSQARDFIAGLGSRPRPGPQMSTFVVESASAGIAVSQRKVRQICDPIQQILIQLHK 995

  Fly   487 HTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQ 551
            .....:.|         || .|||.....||..:.|....:.|...|.     :.::|::..||:
Mouse   996 VIYITQLP---------PA-LHHDLKRRVIERFKKSLFSQQSNPCNLK-----SEIKKLSQGSPE 1045

  Fly   552 ----KFVTYGIENMPPPAVKPAVNP-PPTGVPMQMSV 583
                .|:|....::.........:| .|||.|....|
Mouse  1046 PIELNFLTSDYHSLRHSRAANNWSPSDPTGSPSSFEV 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/287 (34%)
		S_TKc	19..281	CDD:214567	97/286 (34%)
Nek10	NP_001381921.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..72

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000