DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nek2 and EIF2AK2

DIOPT Version :10

Sequence 1:NP_572415.1 Gene:Nek2 / 31696 FlyBaseID:FBgn0029970 Length:735 Species:Drosophila melanogaster
Sequence 2:NP_002750.1 Gene:EIF2AK2 / 5610 HGNCID:9437 Length:551 Species:Homo sapiens


Alignment Length:299 Identity:75/299 - (25%)
Similarity:133/299 - (44%) Gaps:57/299 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 GMDFSQKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQ 72
            ||||.:        :.::|:|.||..:|.:.:..|:.:..|.:.|:. ::|:     .|:..|.:
Human   264 GMDFKE--------IELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-EKAE-----REVKALAK 314

  Fly    73 LQHPNIVQY---------------------------YHHLVNREAKSVYIVMECCAGGDLAQIVQ 110
            |.|.|||.|                           ..:....:.|.::|.||.|..|.|.|.::
Human   315 LDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 379

  Fly   111 RARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARM 175
            :.|.  ::.::.....:..|:.:.:...|:|    .::|||:||:||||......|:|||||...
Human   380 KRRG--EKLDKVLALELFEQITKGVDYIHSK----KLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 438

  Fly   176 LRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMC-ALRPPFR-GRAFDQLSEKI 238
            |:.|.....| .||..|||||.:..:.|.::.|::|:|.::.|:. .....|. .:.|..|.:.|
Human   439 LKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI 502

  Fly   239 AQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIR 277
                   |..|:....:.::..:|:...|.||....|:|
Human   503 -------ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nek2NP_572415.1 STKc_Nek2 18..281 CDD:270857 71/289 (25%)
EIF2AK2NP_002750.1 (Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269|PubMed:17267064 2..180
DSRM_EIF2AK2_rpt1 8..>59 CDD:380732
DSRM_EIF2AK2_rpt2 99..166 CDD:380733
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..222
STKc_EIF2AK2_PKR 260..536 CDD:270949 75/299 (25%)
Interaction with TRAF5. /evidence=ECO:0000269|PubMed:15121867 266..551 73/297 (25%)
Dimerization. /evidence=ECO:0000269|PubMed:16179258 266..362 20/109 (18%)
2 X 13 AA approximate repeats 331..357 0/25 (0%)
Interaction with EIF2S1/EIF-2ALPHA. /evidence=ECO:0000269|PubMed:16179258 379..496 35/123 (28%)
Blue background indicates that the domain is not in the aligned region.

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