DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc2

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_021332870.1	Gene:	herc2 / 558479	ZFINID:	ZDB-GENE-070718-6	Length:	4831	Species:	Danio rerio

Alignment Length:	400	Identity:	81/400 - (20%)
Similarity:	142/400 - (35%)	Gaps:	103/400 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 PAKKLQLSDPSLYESIRREERAEERQVELAEERRRKK-DQEQQKRDQELLK--------EAPSSP 423
            ||....||..|..:.:..:.|.:....:|..:||:|: .::.:..|.|..|        .||.||
Zfish  1515 PAVSNDLSIVSKLKLLSSQPRWKRITQKLIRDRRKKRVPKKSESADLEECKMEGTNEEPPAPLSP 1579

  Fly   424 RALTQ-----------------NIFDEVLKTR--LHAIRA--QESLLQQKLEELQTREQ------ 461
            ..:.:                 |....|.|.|  .|:::.  .:|.|...:.|...:|:
Zfish  1580 APVDKKQTTVKSAKQDKWQPLLNTIGSVQKYRWLRHSVQGSFSQSSLMSTIVEFSLKEEPLDVEK 1644

  Fly   462 -------ELQLAEQRVQTLERQM----QEKLLQQEKHTCSCR-QPIAPPIPPRKPAKSHHDDTYC 514
                   :|:.||.|::.::..:    :..||...::...|. |.:.|            :.|
Zfish  1645 IRKCLLKQLERAEVRLEGIDTMLKLASKNFLLPSVQYAMLCGWQRVIP------------EGT-- 1695

  Fly   515 TIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTG--- 576
                |...|....|....|..|.: ..|.:|||   .|...:.|:|:....::.:|.....|
Zfish  1696 ----NIGEPLADCLKDVDLIPPFN-RMLLEVTF---GKLYAWSIQNVRNILLEASVKFKELGVQP 1752

  Fly   577 VPMQMSVSSNDSGDSQASSTRRK---SILSLFGLSRGSKATSKSLPS-VNQVAQAAATRVQRPPL 637
            ||:|...:.|.:|.|..:..:.:   ::|.:..|..|:.:.|..|.| :..:.|:.        |
Zfish  1753 VPLQTITNENPAGPSLGTIPQARFLLAMLHMLTLKHGANSLSLLLNSGILALTQSV--------L 1809

  Fly   638 AVKPPITQEQPAEVPPVAN----LWTKEQKKQAF---------ELLAAMNAAEREASG-----GG 684
            .:..|.......|:..||:    ...:|.:|:..         ||.|.|..:.|...|     |.
Zfish  1810 RLIGPSCDSSEEELTSVAHGGSATVLEESRKETAPTPLPASGPELAAMMKISTRVMRGPDWKWGD 1874

  Fly   685 VVGSGPGGAR 694
            ..|..||..|
Zfish  1875 QDGPSPGLGR 1884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567
herc2	XP_021332870.1	RCC1	<483..772	CDD:332518
		Cyt-b5	1204..1276	CDD:306642
		MIB_HERC2	1862..1920	CDD:310955	6/22 (27%)
		UBA_HERC2	2453..2499	CDD:270585
		Cul7	2548..2625	CDD:314424
		ZZ_HERC2	2700..2744	CDD:239084
		APC10-HERC2	2759..2902	CDD:176485
		RCC1	2946..3316	CDD:332518
		RCC1	4020..4325	CDD:332518
		HECTc	4418..4789	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010