DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and rpgrb

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001299605.1	Gene:	rpgrb / 557752	ZFINID:	ZDB-GENE-081015-2	Length:	1413	Species:	Danio rerio

Alignment Length:	788	Identity:	141/788 - (17%)
Similarity:	260/788 - (32%)	Gaps:	247/788 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYI 95
            |..|...:|.:|:|    |::.::|...|....|::|        |:                .:
Zfish   210 GALYTFGEKDSGKL----GLSTEKLANHKVPQQVTDI--------PD----------------RV 246

  Fly    96 VMECCAGGDLAQIVQRARSQRQRFEEPYIWRV--LFQLCRALQVCHNKIP--------------- 143
            |...|.||....:.:         .|.|.:.:  ..||.....:..:::|
Zfish   247 VQVACGGGHTVALTE---------NEVYSFGLGQFGQLGHGTFIFESRLPRVVEHFRKGRVKHAA 302

  Fly   144 ---NGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGT--PHYMSPELVKGRKY 203
               |.|.|..|    |..|...|:.:.|..||.     :::|...|..|  |.::.
Zfish   303 CGENHTALITD----NGLLYTFGDGRHGKLGLG-----EENFTNQFKPTLCPRFLD--------- 349

  Fly   204 DRKSDVWAVGCLVYEMCALRPPFRGRAFD--------------------------------QLSE 236
               ..|.:|.|....|..|..|...|..|                                .||.
Zfish   350 ---YHVHSVTCGGCHMLVLAKPRTERPDDLILEEDDVTEDYLEKSYTELLGDTHSQTTLNRSLSA 411

  Fly   237 KIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGED 301
            ::.:.|..|.|..:.    ::...:.|:...|...:.|    |..:|..|:..||.|     ...
Zfish   412 RVRRRERERSPDQFG----QMFRTLPALSGNQSASLSV----PSQIRPSSKQLGKIP-----HNS 463

  Fly   302 FYTLPSGARLFED----EEEDGVHPELSST-----------------------MFTEQYSFNEGY 339
            ..|....|:.|:|    |:.:.| .:|..|                       |..::....:.:
Zfish   464 LKTPGIRAKSFDDRSSVEDSESV-KDLGETTDLLNLTHIMKMDPSDNTLTLSPMEKKKVKVVKEH 527

  Fly   340 GQRRLSVTGVFTP-DLRSELFYSAKRKIFPAKKLQLSDPSL-----------YESIRR------- 385
            |:.:.......|| ..|:||.   .||..|.:.|:.|..|.           ::|.:|
Zfish   528 GKEKGKPRDEPTPYSKRAELL---SRKALPTELLRSSSGSSVVGDSRGLGTPHKSPKRRGHDKEN 589

  Fly   386 -------------------EERAEERQVEL-------AEERRRKKDQEQQKRDQELLKEAPSSPR 424
                               :.||..:.::|       :.::.:|:..|:.:::||:..:......
Zfish   590 VLIALEGRKPGSKTGKGMDKSRAGSKSLKLKHTELMESSDKVKKQSTEKTQQNQEVEVQRSKGTS 654

  Fly   425 ALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQLAEQRV-QTL----ERQMQEKLLQQ 484
            ..||....:. |.:.|.:..:..|.....:|...:.:.:.:.||.: |.|    .:::..|:.:.
Zfish   655 KPTQEGTGKA-KAKDHQLEVKSQLQNVAGKEKGVKSKPIIIVEQHIDQDLTSKNSKEVLPKVQKV 718

  Fly   485 EKHTCSCRQPIAPPIPPRKPAKSHHD--DTYCTIELNETS-PTVAKLNLATLPAPKSLNTLRKVT 546
            :..|..........:|..|.:.|..|  .:..|.|::.|| ||..|...|  ...||....|:|.
Zfish   719 KGDTKIAETENKSFVPQSKKSGSEKDLKSSKTTKEISTTSHPTSGKDTSA--KTKKSRAEQRQVE 781

  Fly   547 FKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDSGDSQASSTRRKSILSLF-GLSRG 610
            .|..:       ..|.|..|..|.:         :|.|:.:|.::|........:.||. |:..|
Zfish   782 DKLKK-------TKMVPTVVSEAAS---------VSESALESEENQMKDNPLTKVTSLLQGMGMG 830

  Fly   611 SKATSKSLPSVNQVAQAAATRV--QRPPLAVKPPITQEQP-AEVPPVANLWTKEQKKQAFELLAA 672
            ..|.        .|.:|.|:::  |..|..:..|:::::. ::|..::..:....:::|.|
Zfish   831 GSAL--------LVGEAVASQLLSQSTPQEMPKPLSRQRTLSDVSSLSESYDVSGQEEARE---- 883

  Fly   673 MNAAEREA 680
               |||.|
Zfish   884 ---AERTA 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	51/303 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	51/303 (17%)
rpgrb	NP_001299605.1	RCC1	54..102	CDD:278826
		RCC1	107..156	CDD:278826
		RCC1_2	143..172	CDD:290274
		RCC1	159..206	CDD:278826
		RCC1	209..259	CDD:278826	15/76 (20%)
		RCC1	261..311	CDD:278826	7/58 (12%)
		RCC1	314..365	CDD:278826	14/67 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010