DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and si:ch211-285c6.3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_017212428.1	Gene:	si:ch211-285c6.3 / 557131	ZFINID:	ZDB-GENE-040724-148	Length:	543	Species:	Danio rerio

Alignment Length:	233	Identity:	74/233 - (31%)
Similarity:	127/233 - (54%)	Gaps:	28/233 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYI--WRVL 128
            :::.|..|.||:||  :|..:.|:...:|:|::.|.|||||:.:::|..|   |.|..|  |.|
Zfish    45 DVNFLLHLDHPHIV--HHKEIIRDGDDLYLVLDHCEGGDLAEKIKQATGQ---FSEKEILDWTV- 103

  Fly   129 FQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPH-- 191
             |:|.||:..|::    .|||:|::|.::...|.|..:||:|        |:.|  :.|.|..
Zfish   104 -QICMALKHLHDQ----QILHKDLQPKSLLFTACGTIRLGEF--------DKWF--TDVQTAETE 153

  Fly   192 ---YMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTD 253
               |.:||.:....|..||::|.:||::.|||.|:..|.....|::.:||.:..:..:|..:|.|
Zfish   154 SLAYFAPENLHDTSYYEKSEIWRLGCIICEMCTLKKAFSSGNTDEIIKKICRSSYEHLPTNFSED 218

  Fly   254 LQEIIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGK 291
            |||:|...|.|:...||.:..|:..|.:::::.|:..|
Zfish   219 LQELIKDTLQVNPADRPSVSEILMRPFIIKHLREMSKK 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	72/221 (33%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	72/221 (33%)
si:ch211-285c6.3	XP_017212428.1	PKc_like	23..246	CDD:304357	72/221 (33%)
		S_TKc	25..246	CDD:214567	72/221 (33%)
		ApoL	260..>347	CDD:283187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840