Protein Alignment Nek2 and nek1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_009292952.1
• Gene: nek1 / 556002
• ZFINID: ZDB-GENE-040730-1
• Length: 1413
• Species: Danio rerio
• Alignment Length: 912
• Identity: 209/912 - (22%)
• Similarity: 325/912 - (35%)
• Gaps: 299/912 - (32%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :..||.|..:|.||||....|:.::.|..:..|.:....:...:......|::||..:.||||||
Zfish     1 MDKYERLKKIGEGSFGKAILVKSRTDGRQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            |....  .|:..:||||:.|.||||.:.:...|.  ..|.|..|.....|:|.||:..|::
Zfish    66 YKESF--EESGCLYIVMDYCEGGDLFKKINNQRG--SLFPEEQILDWFVQICLALKHVHDR---- 122

  Fly   146 TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVW 210
            .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:|
Zfish   123 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIW 187

  Fly   211 AVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVI 275
            |:||::||||.|:..|.......|..||.:|.:..:...||.||:.::|.:...:..:||.:..|
Zfish   188 ALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSIHYSPDLRSLLAQLFKRNPRERPSVSTI 252

  Fly   276 IRHPLVVRNISELDGKF--PILVDSGEDF-------------YTLPSGARLFEDEEEDGVHPELS 325
            :..|.:.|.|.    ||  |.|:  .::|             :..|:      .....|..|..|
Zfish   253 LDKPFLARRIH----KFLSPQLI--AQEFSHSIHLQPKMSVAHAAPA------KRPAPGPIPITS 305

  Fly   326 STMFTEQYSFNEGYG----QRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRRE 386
            :...|:..:   .||    .||.|......||       :||:   |.|..|...|:..:  ||.
Zfish   306 AQKITKPAA---KYGVPLTVRRPSEVARKVPD-------AAKK---PVKLKQAPPPAAVQ--RRV 355

  Fly   387 ERAEERQVELAEERRRKK----DQEQQKRDQELLKEA---------------------------- 419
            .|.||.:.:..|..|:|:    ::|:::|:|.||.:|
Zfish   356 SRVEEERRKHEEGVRKKRMEMMERERKQREQMLLLKAAQMKRFEREKLNRINRAREQGWRHVLSS 420

  Fly   420 ------------------------------------PSSPRALTQNIFD---------------- 432
                                                |||..|.::..:|
Zfish   421 SGGSSPERKFYGGGGGNGAPHSPGISPFPVPGPSPVPSSALAPSRAPYDRIHPSAEKLTKPTPKD 485

  Fly   433 ------------------------------------EVLKTRL---------HAIRAQESLLQQK 452
                                                |..||.|         :|.|.:..|..:|
Zfish   486 GAGEGAVHAGDNGRTSSDSGTLNGHACIPVKNGVRKEQRKTSLQNEQISKIDYANRFRGQLAVEK 550

  Fly   453 ---LEELQTREQELQLAEQRV--QTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDT 512
               :||...|::|..|.:.|.  |...||....:.....::..|          |:|..:..::.
Zfish   551 SKQVEEFLQRKREAMLNKVRAEGQLGARQNLAAIFASWTNSSRC----------RRPRVNKEEEE 605

  Fly   513 YCT----IEL---NETSPTVAK---------------------LNLATLPAPKSLNTLRKVTFK- 548
            |.|    |.|   ||.....|:                     |.:..:.|.|:.:..|....|
Zfish   606 YLTRLRQIRLQNFNERQQIKARLRGEKYDSDGSDSQESCEEAVLRMKKIEALKAQSKARAAVLKE 670

  Fly   549 -----------------SPQKFVTYGIE-------NMPPPAVKPA--VNPPPTGVPMQMSVSSND 587
                             ...:.|..|::       ..|.||..|.  .:|.|...|.:.:.||..
Zfish   671 QLEKKRREAYEREKKAWEDHQLVARGVKVAVGPVGGTPSPAAPPTPPSDPTPQEAPSKATPSSRP 735

  Fly   588 SGDSQASSTRRKSILSLFGLSRGSKATSKS-----------------LPSVNQVAQAA-ATRVQR 634
            |..:.:.:...|.:   ..:|.|..:..|.                 |..:||..|.. ...|:.
Zfish   736 STPAISMTAALKDV---GAISSGQSSPMKEDSLKVESSDVQSDKKEILRRLNQKVQTTEEVSVKE 797

  Fly   635 P----------PLAVKPPITQEQP----------AEVPPVANLWTKEQKKQAFELLAAMNAAERE 679
            |          |..|:|.||:|:|          |..||:.::     .:|..|...|..|..:.
Zfish   798 PTPSSNQPCPDPQPVQPSITEERPSTAADRKKWEAVAPPILSV-----AEQTLEETCATLAVSQV 857

  Fly   680 AS 681
            ||
Zfish   858 AS 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/262 (36%)
nek1	XP_009292952.1	STKc_Nek1	3..258	CDD:270858	95/262 (36%)