DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and nek12

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001017548.1	Gene:	nek12 / 548344	ZFINID:	ZDB-GENE-050410-11	Length:	488	Species:	Danio rerio

Alignment Length:	489	Identity:	134/489 - (27%)
Similarity:	232/489 - (47%)	Gaps:	70/489 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKC-DALVSEISVLRQLQHPNIV 79
            ::.|:.:..:|.|..|....::...|.:|.|.|.::.|...:.|. |.::.|..|||.|:||:|:
Zfish     1 MEKYDKVLTLGQGGAGVVSLMKHVDTKKLCAVKRIHVDSSRKTKTKDVVLQEAIVLRSLKHPHII 65

  Fly    80 QYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            .:.....:...:|:||||:.|.||.|...::..:. .:.|.|..|.....|:..|:...|::
Zfish    66 TWIDTFFDATNESIYIVMDYCDGGTLDDHIKEQKC-GEHFTESNIMDWFVQVVMAVSYIHSE--- 126

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .||||||||:|:.|...|..||||||:::::......|::.||||.|:||||.:...|..|||:
Zfish   127 -KILHRDIKPSNVLLTKRGVIKLGDFGISKIMNHTLDMASTCVGTPSYLSPELCQDVPYSTKSDI 190

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||||||:||:|||:|.|:.:....|..||.:||:.::|.:||.|:..:|..||::..|.||....
Zfish   191 WAVGCLLYELCALKPAFQAKNLLSLFYKIIKGEYIKVPEMYSEDIHTLIEKMLSLIPENRPSAAS 255

  Fly   275 IIRHPLVVRNISELDGKF----------------PILVDSGEDFYTLPSGAR------LFED--- 314
            |:....|..::    |.|                |   .:.||| |:...:|      :|:.
Zfish   256 ILSMTYVQEHL----GNFITNQEKELTKVNAESRP---QTKEDF-TVDMESRTDCASAVFDKTLE 312

  Fly   315 ------EEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKL- 372
                  .||:..| |.:.:.::|.:..::.|.    |...|...|..|.|...|:.....:..:
Zfish   313 IEMSGIAEEEVAH-EGTESDYSEDFDEHDSYA----SSEDVSREDGSSSLANVAEEAFEESSAVF 372

  Fly   373 ---QLSD-PSLYESIRREERAE----ERQVELAEERRRKKDQEQQKRD-------QELLKEAPSS 422
               ::|| |..:|....::.||    .|.|..:.......|.|.:.:|       .::|||  ..
Zfish   373 EDEEISDYPDDFEEAEDDDLAEVVSYARDVINSSSENDVFDVELELKDADGFSVTMKMLKE--KY 435

  Fly   423 PRALTQNIFDEVLKTRLHAIRAQESLLQQKLEEL 456
            ...:..::::|:.:..|:.:..::  ||.:.:.:
Zfish   436 MEDVGASVYEEISEHFLNGLTPED--LQPQFQHM 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	94/263 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	94/262 (36%)
nek12	NP_001017548.1	STKc_Nek	3..262	CDD:270855	94/263 (36%)
nek12	NP_001017548.1	S_TKc	4..262	CDD:214567	94/262 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920