DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and HERC5

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	514	Identity:	110/514 - (21%)
Similarity:	175/514 - (34%)	Gaps:	136/514 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPN 77
            |.|..||..||:              ...|||||| |.|           |..::.|.|:.....
Human   293 QITCGDYHSLAL--------------SKGGELFAW-GQN-----------LHGQLGVGRKFPSTT 331

  Fly    78 IVQYYHHLVNREAKSVYIVMECCAGGDLAQI-VQRARSQRQRFE-EPYIWRVLFQLCRALQVCHN 140
            ..|...||               ||..|||| ...|.|...... ..|.|..  ..|..|.:.|.
Human   332 TPQIVEHL---------------AGVPLAQISAGEAHSMALSMSGNIYSWGK--NECGQLGLGHT 379

  Fly   141 KIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQ---SFAASFVG------TPHYMSPE 196
            :..:...|...:....:...|.|.:.      :.:|.:|.   :|.|...|      |.:.:.|
Human   380 ESKDDPSLIEGLDNQKVEFVACGGSH------SALLTQDGLLFTFGAGKHGQLGHNSTQNELRP- 437

  Fly   197 LVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFM 261
                             |||.|:...|           ..:||.|.:..:  .|.:||.::.:|.
Human   438 -----------------CLVAELVGYR-----------VTQIACGRWHTL--AYVSDLGKVFSFG 472

  Fly   262 LAVDHEQRPG--IEVIIRHPLVVRNISEL------DGKFPILVDSGEDFYTLPSGARLFEDEEED 318
            ...|.:...|  .:.::..|:.|.:..||      ..|..|::..|.      ....|:..:|..
Human   473 SGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGN------QSILLWIKKENS 531

  Fly   319 GVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESI 383
            .|:  |..|:.|    .|||..:|.::       |:.::.:.|.||:|   :::..|...|..|.
Human   532 YVN--LKRTIPT----LNEGTVKRWIA-------DVETKRWQSTKREI---QEIFSSPACLTGSF 580

  Fly   384 RREERAEERQ-VELAEERRRKKDQEQQKRD-----------QELLKEAP--SSPRALTQNIFDEV 434
            .|:.|..|.. |.|...:.|...:|..::|           ..|||..|  |.|:...:..|...
Human   581 LRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLLP 645

  Fly   435 LKTRLHAIRAQESLLQQKLEEL-QTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCR 492
            ....:|.....|||:....:.: :..:|...:.|:...||:.....||:|..|....|:
Human   646 ECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQ 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	56/275 (20%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	55/274 (20%)
HERC5	XP_011530324.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010