DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and NEK3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_002489.1	Gene:	NEK3 / 4752	HGNCID:	7746	Length:	506	Species:	Homo sapiens

Alignment Length:	457	Identity:	131/457 - (28%)
Similarity:	213/457 - (46%)	Gaps:	101/457 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGM----NYDELDEAKCDALVSEISVLRQLQHP 76
            :.||.||.::|.||||....|:.:|:.::||.|.:    ::.....::.:|:     :|.:::||
Human     1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAV-----LLAKMKHP 60

  Fly    77 NIVQYYHHLVNREAKS-VYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHN 140
            |||.:....   ||:. :|||||.|.||||.|.:::.:.  :.|.|..|.....|:|..:...|.
Human    61 NIVAFKESF---EAEGHLYIVMEYCDGGDLMQKIKQQKG--KLFPEDMILNWFTQMCLGVNHIHK 120

  Fly   141 KIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDR 205
            |    .:||||||..||||...|..||||||.||:|....:||.::||||:|:.||:.:...|:.
Human   121 K----RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181

  Fly   206 KSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRP 270
            |||:|::||::||:|.|:.||:..::..|..|:.||..|.:|:.||.:||.::..|...:...||
Human   182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRP 246

  Fly   271 GIEVIIRHPLVVRNISELDGKFP--ILVDSGEDFY--------------TLPSGARL-------- 311
            ....::...:|.|.:.:.   .|  |:::.||:..              |.||..|:
Human   247 SATTLLSRGIVARLVQKC---LPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIALGNEAST 308

  Fly   312 FEDEEED--GVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQL 374
            .::||:|  |.|.:|.|                           :...|..||.|:
Human   309 VQEEEQDRKGSHTDLES---------------------------INENLVESALRR--------- 337

  Fly   375 SDPSLYESIRREERAEERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRL 439
                    :.|||:. .:.|.|    |:.......:|..|  |..|::.....:|.  .:|.:.|
Human   338 --------VNREEKG-NKSVHL----RKASSPNLHRRQWE--KNVPNTALTALENA--SILTSSL 385

  Fly   440 HA 441
            .|
Human   386 TA 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	96/267 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	95/266 (36%)
NEK3	NP_002489.1	Interaction with VAV2. /evidence=ECO:0000269\|PubMed:15618286	1..285		102/300 (34%)
		STKc_Nek3	3..257	CDD:173759	96/267 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..325		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920