| Sequence 1: | NP_572415.1 | Gene: | Nek2 / 31696 | FlyBaseID: | FBgn0029970 | Length: | 735 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002488.1 | Gene: | NEK2 / 4751 | HGNCID: | 7745 | Length: | 445 | Species: | Homo sapiens |
| Alignment Length: | 501 | Identity: | 181/501 - (36%) |
|---|---|---|---|
| Similarity: | 263/501 - (52%) | Gaps: | 100/501 - (19%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 17 QDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQY 81
Fly 82 YHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG- 145
Fly 146 TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVW 210
Fly 211 AVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVI 275
Fly 276 IRHPLVV--------RNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQ 332
Fly 333 YSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIR----REERAEERQ 393
Fly 394 VELAEERRRKKDQ----EQQKRDQELLKE-----APSSPRALTQNIFDEVLKTRLH--------A 441
Fly 442 IRAQESLLQ----QKLEELQTREQELQLAEQRVQTLERQMQEKLLQ 483 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Nek2 | NP_572415.1 | STKc_Nek2 | 18..281 | CDD:270857 | 132/263 (50%) |
| S_TKc | 19..281 | CDD:214567 | 131/262 (50%) | ||
| NEK2 | NP_002488.1 | STKc_Nek2 | 7..271 | CDD:270857 | 132/263 (50%) |
| Interaction with PCNT. /evidence=ECO:0000269|PubMed:20599736 | 264..445 | 51/243 (21%) | |||
| Interaction with CEP85. /evidence=ECO:0000269|PubMed:26220856 | 301..445 | 42/187 (22%) | |||
| Leucine-zipper | 306..334 | 10/27 (37%) | |||
| Necessary for interaction with MAD1L1. /evidence=ECO:0000269|PubMed:14978040 | 329..445 | 29/114 (25%) | |||
| Required for microtubule binding and for localization to the centrosomes | 333..370 | 10/36 (28%) | |||
| Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000269|PubMed:21076410 | 403..439 | 10/35 (29%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 282 | 1.000 | Domainoid score | I1670 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 293 | 1.000 | Inparanoid score | I2783 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D132059at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000168 | |
| OrthoInspector | 1 | 1.000 | - | - | oto91614 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104455 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR43671 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R445 |
| SonicParanoid | 1 | 1.000 | - | - | X4876 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 11 | 10.960 | |||||