DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nek2 and NEK2

DIOPT Version :10

Sequence 1:NP_572415.1 Gene:Nek2 / 31696 FlyBaseID:FBgn0029970 Length:735 Species:Drosophila melanogaster
Sequence 2:NP_002488.1 Gene:NEK2 / 4751 HGNCID:7745 Length:445 Species:Homo sapiens


Alignment Length:501 Identity:181/501 - (36%)
Similarity:263/501 - (52%) Gaps:100/501 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 QDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQY 81
            :|||||..:|.||:|.|.|:|.||.|::..||.::|..:.||:...||||:::||:|:|||||:|
Human     6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRY 70

  Fly    82 YHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG- 145
            |..:::|...::|||||.|.|||||.::.:...:||..:|.::.||:.||..||:.||.:...| 
Human    71 YDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGH 135

  Fly   146 TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVW 210
            |:||||:||||:|||...|.|||||||||:|..|.|||.:|||||:|||||.:....|:.|||:|
Human   136 TVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIW 200

  Fly   211 AVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVI 275
            ::|||:||:|||.|||...:..:|:.||.:|:|.|||..||.:|.|||..||.:....||.:|.|
Human   201 SLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEI 265

  Fly   276 IRHPLVV--------RNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQ 332
            :.:||:.        ||:..                   .|.:|.|.|:.....|.||       
Human   266 LENPLIADLVADEQRRNLER-------------------RGRQLGEPEKSQDSSPVLS------- 304

  Fly   333 YSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIR----REERAEERQ 393
                                                  :|:|.:..|.|..|    ||||.|:::
Human   305 --------------------------------------ELKLKEIQLQERERALKAREERLEQKE 331

  Fly   394 VELAEERRRKKDQ----EQQKRDQELLKE-----APSSPRALTQNIFDEVLKTRLH--------A 441
            .||....|..:|:    |...::..||||     ..|:|..|  |:...|:|.::|        .
Human   332 QELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELL--NLPSSVIKKKVHFSGESKENI 394

  Fly   442 IRAQESLLQ----QKLEELQTREQELQLAEQRVQTLERQMQEKLLQ 483
            :|::.|..|    .|.::|:.|....||..|.:..:|:..|.|..|
Human   395 MRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQ 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nek2NP_572415.1 STKc_Nek2 18..281 CDD:270857 132/263 (50%)
NEK2NP_002488.1 STKc_Nek2 7..271 CDD:270857 132/263 (50%)
Interaction with PCNT. /evidence=ECO:0000269|PubMed:20599736 264..445 51/243 (21%)
Interaction with CEP85. /evidence=ECO:0000269|PubMed:26220856 301..445 42/187 (22%)
Leucine-zipper 306..334 10/27 (37%)
Necessary for interaction with MAD1L1. /evidence=ECO:0000269|PubMed:14978040 329..445 29/114 (25%)
Required for microtubule binding and for localization to the centrosomes 333..370 10/36 (28%)
Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000269|PubMed:21076410 403..439 10/35 (29%)

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