DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and NEK1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001186326.1	Gene:	NEK1 / 4750	HGNCID:	7744	Length:	1286	Species:	Homo sapiens

Alignment Length:	772	Identity:	189/772 - (24%)
Similarity:	307/772 - (39%)	Gaps:	234/772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|..|..:|.||||....|:....|..:..|.:|...:...:.:....|::||..::||||||
Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
Human    66 YRESF--EENGSLYIVMDYCEGGDL---FKRINAQKGVLFQEDQILDWFVQICLALKHVHDR--- 122

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
Human   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:|.|:..|...:...|..||..|.|..:...||.||:.:::.:...:...||.:..
Human   187 WALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNS 251

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQY---SFN 336
            |:....:.:.|.    ||                               ||..:..|::   :|:
Human   252 ILEKGFIAKRIE----KF-------------------------------LSPQLIAEEFCLKTFS 281

  Fly   337 EGYGQRRLSVTGVFTPDLRSELFYSAKR--------KIFPAKKL--------------QLSDPSL 379
            : :|.:.:                .|||        .:.||:|:              :..|..|
Human   282 K-FGSQPI----------------PAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKL 329

  Fly   380 YES--IRREERAE---ERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRL 439
            :|.  :::.::|.   |::|...||||:..::..:||..|.:::.....        |:::
Human   330 HEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQK--------DQII---- 382

  Fly   440 HAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSC------RQP---- 494
                   ||:  |.|:::.:|:|      |::.:.|..:    |..::..|.      :.|
Human   383 -------SLM--KAEQMKRQEKE------RLERINRARE----QGWRNVLSAGGSGEVKAPFLGS 428

  Fly   495 ---IAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTY 556
               |||.....:....|:...:..::........||..             |::          |
Human   429 GGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWK-------------REI----------Y 470

  Fly   557 GIENMPPPAVKPAVNPPPTGVPMQMSVSSN--DSGDSQASSTRRKSILSLFGLSRGSKATSKSLP 619
            | ..:|...:.|.|.|   |.|...:...:  |:.|.      ||::..|       ||.||
Human   471 G-RGLPERGILPGVRP---GFPYGAAGHHHFPDADDI------RKTLKRL-------KAVSK--- 515

  Fly   620 SVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELL-----AAMNAAERE 679
                  ||.|.| |:..|||                     |:.||..|.|     |..|.|..|
Human   516 ------QANANR-QKGQLAV---------------------ERAKQVEEFLQRKREAMQNKARAE 552

  Fly   680 ----------ASGGGVVGSGPGGARRQ--------HLRQSVRERNSTLQRNRMRRSL 718
                      |..||...|..||..|.        .||| :|.:|.. :|.:::..|
Human   553 GHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQ-IRLQNFN-ERQQIKAKL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	95/262 (36%)
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920