Protein Alignment Nek2 and NEK1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 772
• Identity: 189/772 - (24%)
• Similarity: 307/772 - (39%)
• Gaps: 234/772 - (30%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|..|..:|.||||....|:....|..:..|.:|...:...:.:....|::||..::||||||
Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
Human    66 YRESF--EENGSLYIVMDYCEGGDL---FKRINAQKGVLFQEDQILDWFVQICLALKHVHDR--- 122

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
Human   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:|.|:..|...:...|..||..|.|..:...||.||:.:::.:...:...||.:..
Human   187 WALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNS 251

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQY---SFN 336
            |:....:.:.|.    ||                               ||..:..|::   :|:
Human   252 ILEKGFIAKRIE----KF-------------------------------LSPQLIAEEFCLKTFS 281

  Fly   337 EGYGQRRLSVTGVFTPDLRSELFYSAKR--------KIFPAKKL--------------QLSDPSL 379
            : :|.:.:                .|||        .:.||:|:              :..|..|
Human   282 K-FGSQPI----------------PAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKL 329

  Fly   380 YES--IRREERAE---ERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRL 439
            :|.  :::.::|.   |::|...||||:..::..:||..|.:::.....        |:::
Human   330 HEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQK--------DQII---- 382

  Fly   440 HAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSC------RQP---- 494
                   ||:  |.|:::.:|:|      |::.:.|..:    |..::..|.      :.|
Human   383 -------SLM--KAEQMKRQEKE------RLERINRARE----QGWRNVLSAGGSGEVKAPFLGS 428

  Fly   495 ---IAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTY 556
               |||.....:....|:...:..::........||..             |::          |
Human   429 GGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWK-------------REI----------Y 470

  Fly   557 GIENMPPPAVKPAVNPPPTGVPMQMSVSSN--DSGDSQASSTRRKSILSLFGLSRGSKATSKSLP 619
            | ..:|...:.|.|.|   |.|...:...:  |:.|.      ||::..|       ||.||
Human   471 G-RGLPERGILPGVRP---GFPYGAAGHHHFPDADDI------RKTLKRL-------KAVSK--- 515

  Fly   620 SVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELL-----AAMNAAERE 679
                  ||.|.| |:..|||                     |:.||..|.|     |..|.|..|
Human   516 ------QANANR-QKGQLAV---------------------ERAKQVEEFLQRKREAMQNKARAE 552

  Fly   680 ----------ASGGGVVGSGPGGARRQ--------HLRQSVRERNSTLQRNRMRRSL 718
                      |..||...|..||..|.        .||| :|.:|.. :|.:::..|
Human   553 GHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQ-IRLQNFN-ERQQIKAKL 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)