DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and nek8

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_012812229.1	Gene:	nek8 / 448753	XenbaseID:	XB-GENE-990378	Length:	698	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	121/414 - (29%)
Similarity:	198/414 - (47%)	Gaps:	72/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|:.:.|:|.|:||..:....|:..:|...|.:..:::.:.:..|..:|..||:.|.||||::
Frog     1 MEKYKKIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIE 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            ||.:.:  |.|::.||||...||.||:.:|:..:  ...:|..|.....|:..||...|.|:
Frog    66 YYENFL--EDKALMIVMEYAPGGTLAEYIQKRCN--SLLDEDTILHFFVQILLALHHVHTKL--- 123

  Fly   146 TILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             |||||:|..||.||.... .|:||||::::| ..:|.|.:.||||.|:||||.:|:.|::|||:
Frog   124 -ILHRDLKTQNILLDKHQMIVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCEGKPYNQKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:.:|:..|.......|..||..|.|:.|...||.:|:.:|..||.:|..:||.:..
Frog   187 WALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNE 251

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYT------------------------LPS----GARL 311
            |:.||:.:          |.|::...|..:                        :||    |.|:
Frog   252 IMAHPICI----------PALLNLYSDIGSVKMRRVEKPLASVPAVSRVRPASRIPSARSRGGRV 306

  Fly   312 FEDEEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFY-------------SAK 363
            .....:.|:.|.|||.     |::..|..      |.:..|.|.:|:..             |.:
Frog   307 GHSPAKPGIPPPLSSV-----YTWGSGIS------TPLRLPMLNTEVVQVSAGRTQKAGVTKSGR 360

  Fly   364 RKIFPAKKLQLSDPSLYESIRREE 387
            ..::.|..:....|||..||...:
Frog   361 LIMWEATPVGTGAPSLPGSIEHAQ 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	96/263 (37%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	96/262 (37%)
nek8	XP_012812229.1	STKc_Nek8	3..258	CDD:270859	96/263 (37%)
		S_TKc	4..256	CDD:214567	94/260 (36%)
		ATS1	320..657	CDD:227511	15/76 (20%)
		RCC1	421..465	CDD:278826
		RCC1	470..517	CDD:278826
		RCC1	587..635	CDD:278826
		RCC1	638..687	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040