DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and niki

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	101/292 - (34%)
Similarity:	166/292 - (56%)	Gaps:	10/292 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGEESAGMDFSQKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVS 65
            :|.....|:..:...|.:||.:.|:|.||||.....|.||.|....:|.:|..||.....|..::
  Fly    87 LSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMN 151

  Fly    66 EISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQ 130
            |:.|..:|.|||||.|....:  :..::.|.||...||.||||:.. |..:..|.|.||..|..|
  Fly   152 EVDVFSKLHHPNIVSYLGSFI--KDNTLLIEMEYADGGTLAQIIAE-RQGKLHFPERYIIAVFEQ 213

  Fly   131 LCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSP 195
            :..|:...|::    .|||||:|.||:||:..|..|:||||::::: ..:..|.:.:|||:|.||
  Fly   214 ISSAINYMHSE----NILHRDLKTANVFLNRRGIVKIGDFGISKIM-NTKIHAQTVLGTPYYFSP 273

  Fly   196 ELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAF 260
            |:.:|::||.|||:||:||::.|||.|:..|......:|..||..|.::.:|:.|::.|:.:::.
  Fly   274 EMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSN 338

  Fly   261 MLAVDHEQRPGIEVIIRH--PLVVRNISELDG 290
            :|.|:..:||....::.:  ||:.|::.:..|
  Fly   339 LLQVEAPRRPTASEVLVYWIPLIFRSLGKNKG 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/264 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	95/263 (36%)
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	94/262 (36%)
		S_TKc	105..354	CDD:214567	94/256 (37%)
		ATS1	445..747	CDD:227511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		mtm947
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43671
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.980