DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and rcc2

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_998341.1	Gene:	rcc2 / 406455	ZFINID:	ZDB-GENE-040426-2213	Length:	495	Species:	Danio rerio

Alignment Length:	152	Identity:	32/152 - (21%)
Similarity:	51/152 - (33%)	Gaps:	47/152 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 NGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVK---GRKY-- 203
            |||:.            ..|..|||..|     :.:|:.|.....|..|....:||   |.::
Zfish   193 NGTVY------------TFGENKLGQLG-----QGNQTDAVLSPATIQYNGQPIVKVACGAEFSM 240

  Fly   204 --DRKSDVWAVGCLVYEM-------------------CALRPPFRGRAFDQLSEKIAQGEFSRIP 247
              |.|.::::.||..|..                   |.|.|    |......||...|:...:|
Zfish   241 IVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIP----RRVAIFIEKTKDGQVLPVP 301

  Fly   248 AIYSTDLQEIIAFMLAVDHEQR 269
            .:.:.|:.......|.:|.::|
Zfish   302 NVVARDVACGANHTLVLDSQKR 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	32/152 (21%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	32/152 (21%)
rcc2	NP_998341.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		RCC1 1	76..138
		RCC1_2	121..154	CDD:290274
		RCC1 2	141..192
		RCC1	141..190	CDD:278826
		RCC1	193..242	CDD:278826	15/65 (23%)
		RCC1 3	194..244		14/66 (21%)
		RCC1	245..318	CDD:278826	14/76 (18%)
		RCC1 4	246..320		13/77 (17%)
		Required for interaction with RAC1. /evidence=ECO:0000250\|UniProtKB:Q9P258	291..298		2/6 (33%)
		RCC1 5	321..374		1/3 (33%)
		RCC1	323..372	CDD:278826	1/1 (100%)
		RCC1 6	376..420
		RCC1 7	421..474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010