Protein Alignment Nek2 and nek4

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_957306.1
• Gene: nek4 / 393987
• ZFINID: ZDB-GENE-040426-1392
• Length: 849
• Species: Danio rerio
• Alignment Length: 857
• Identity: 207/857 - (24%)
• Similarity: 311/857 - (36%)
• Gaps: 235/857 - (27%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :..|..:.|:|.||:|....||.||..:.:..|.:|.......:..|...|..:|.||:|||||.
Zfish     1 MDGYLFVRVVGKGSYGEVNLVRHKSDRKQYVIKKLNLRTSSRRERRAAEQEAQLLSQLKHPNIVM 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARS----QRQRFEEPYIWRVLFQLCRALQVCHNK 141
            |.......:.: :||||..|.||||...:::.:.    :||..|    |.|  |:..|||..|.|
Zfish    66 YRESWEGEDCQ-LYIVMGFCEGGDLYHRLKQQKGELLPERQVVE----WFV--QIAMALQYLHEK 123

  Fly   142 IPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRK 206
                .|||||:|..||||......|:||.|:||:|......|::.:|||:||||||...:.|:.|
Zfish   124 ----HILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYK 184

  Fly   207 SDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPG 271
            |||||:||.||||..|:..|..:..:.|..:|.:|:..::|:.|...|.|:|..||....|.||.
Zfish   185 SDVWALGCCVYEMATLKHAFNAKDMNSLVYRIVEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPD 249

  Fly   272 IEVIIRHPLVVRNIS----------------ELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGV 320
            ::.|:|.|.:...||                ..:||   |..:|.|..|.|:..          |
Zfish   250 VKHILRQPYIKHQISMFLEATKEKTAKSRKNAANGK---LNSAGSDASTKPNQV----------V 301

  Fly   321 HPE-LSSTMFTEQYSFNEGYGQRRLSVTGVF--------------TPDLRS------------EL 358
            .|: |:|...|......|.|..|:....|.:              |.|:.:            ::
Zfish   302 QPQCLNSESKTCGKKAEEIYLNRQKPCNGAWENVAPKHHMPPKSPTRDIHNSTGQSIATISNIDI 366

  Fly   359 FYSAKRKIFPAKKLQLSDPSLYESIRREERAE--------ERQV--------------------- 394
            ....:||..|.|.....:.:|....:|.|:.:        .:||
Zfish   367 EIQKQRKAKPPKPSSHQNNNLPSVSKRREKEDPGAPQTHPHKQVSGVGGTEDKMSANASSITPKP 431

  Fly   395 ------------------------ELAEE---------------RRRKKDQEQQKRDQE----LL 416
                                    :|.:|               ...:|.:.|:..|.:    :|
Zfish   432 ADRTKMPNKSKALDVSLDIKDDTMKLLQEAGVQDLPYEPTELHHNAEQKTESQRTADNQSNAGVL 496

  Fly   417 KEAPS------SPRALTQN---------IFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQLA 466
            |:||:      |..:|...         ||.|..::...|..:.|........|.....|..|..
Zfish   497 KDAPTGSSTEESEGSLDSTEKLLKPVPVIFMEPSRSESPAALSDEGRPSSSSSEPSMSRQRRQRR 561

  Fly   467 EQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLA 531
            :.:.|.|:..:|||:          .:|: ||:|  :...|...|......|:.|:.:..:.|
Zfish   562 KDKSQDLQNGIQEKV----------SRPL-PPLP--EDGNSAQKDQSTPAGLSSTNKSTEQQN-- 611

  Fly   532 TLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTGVP------------------ 578
               .|.|....|::  |..|       ||....||. ||..|...||
Zfish   612 ---RPLSARERRRL--KQSQ-------ENSTQQAVS-AVKRPSCDVPSLDSEQIHQTDCPRAART 663

  Fly   579 ---------MQMSVSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQR 634
                     .....|..|...|..|||.|..     |..|..|..|..:..:.| .......:..
Zfish   664 TVDTTKERKSSRKQSDEDECSSSTSSTERSE-----GDYRERKCESNEMQDLVQ-TMTQTLHMDG 722

  Fly   635 PPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELLAAMNAAEREASGG-GVVG------SGPGG 692
            ...:.:|...:.....:|..     |..:|....|:  ::...|||.|. .:.|      :||..
Zfish   723 KDASFEPDGPRCHSTPLPEF-----KLNRKYRDTLM--LHGKSREAQGDLQITGFPLDDSTGPAK 780

  Fly   693 ARR--QHLRQSV 702
            .||  :|||..|
Zfish   781 VRRVIEHLRTDV 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	101/266 (38%)
nek4	NP_957306.1	STKc_Nek4	3..259	CDD:270862	101/266 (38%)