DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and Herc3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001102101.1	Gene:	Herc3 / 362377	RGDID:	1307803	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	229	Identity:	37/229 - (16%)
Similarity:	69/229 - (30%)	Gaps:	94/229 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGG 103
            :|..||..:.|   ::::|..|                     .:..|.||:..|....:...||
  Rat   836 RSLQELLDYPG---EDIEETFC---------------------LNFTVCRESYGVIEQKKLIPGG 876

  Fly   104 DLAQIVQRARSQRQRFEEPYIWRVLFQL----------CRALQVCHNK--------------IPN 144
            |...:   .:..||.|.:.|: ..:||:          ...|:||..|              :.|
  Rat   877 DRVAV---CKDNRQEFVDAYV-NYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGN 937

  Fly   145 GTILHRDIKPANIF------------------------------LDAAGNAKLGDFGLARMLRRD 179
            ......:::...::                              |...|:.::..:|:|.:....
  Rat   938 SNYNWEELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRFLLFLTGSDRIPIYGMASLQIVI 1002

  Fly   180 QSFAA------------SFVGTPHYMSPELVKGR 201
            ||.|.            :.:..|.|.|.|::|.|
  Rat  1003 QSTATGEDYLPVAHTCYNLLDLPKYSSKEIMKAR 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	37/229 (16%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	37/229 (16%)
Herc3	NP_001102101.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:395335
		HECTc	702..1048	CDD:238033	37/229 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010