DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nek2 and NEK5

DIOPT Version :9

Sequence 1:NP_572415.1 Gene:Nek2 / 31696 FlyBaseID:FBgn0029970 Length:735 Species:Drosophila melanogaster
Sequence 2:NP_001352481.1 Gene:NEK5 / 341676 HGNCID:7748 Length:832 Species:Homo sapiens


Alignment Length:883 Identity:192/883 - (21%)
Similarity:332/883 - (37%) Gaps:228/883 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :..|:|:..:|.|:||..|..:.||..:....|.:|::::...:.:|...|:.:|.:::|||||.
Human     1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVA 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR---FEEPYIWRVLFQLCRALQVCHNKI 142
            :::..  :|...::||||.|.||||.:     |..|||   |.|..|.....|:...|:..|:: 
Human    66 FFNSF--QENGRLFIVMEYCDGGDLMK-----RINRQRGVLFSEDQILGWFVQISLGLKHIHDR- 122

  Fly   143 PNGTILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRK 206
               .|||||||..||||...|. |||||||:||:|......|.:.:|||:|:|||:.:.:.|:.|
Human   123 ---KILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNK 184

  Fly   207 SDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPG 271
            :|:|::||::||:|.|:.||.|....||..||.|..|:.|...:|.:|..:|:.:..|....||.
Human   185 TDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPS 249

  Fly   272 IEVIIRHPLVVRNISE----------------------------------------LDGKFP--- 293
            |..|::.|.:...|.:                                        ..||.|   
Human   250 INSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPPRS 314

  Fly   294 ---------ILVDSGEDFYTLPSGAR-----------------------------LFEDEEEDGV 320
                     .::...|  :..|:||:                             |.....:...
Human   315 RISVPIKRNAILHRNE--WRPPAGAQKARSIKMIERPKIAAVCGHYDYYYAQLDMLRRRAHKPSY 377

  Fly   321 HPELSSTMFTEQYSFNEGYGQ--RRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYE-- 381
            ||      ..::.:..|.|||  |.......:..:.....|.:.:.|:...|:|.|. ||..|  
Human   378 HP------IPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLR-PSSAEPN 435

  Fly   382 -SIRREERA---EERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDE-----VLKT 437
             :.|:|.|:   |.|..||...:...|:||..|:.:|:.::..:..:.:.:.:..|     .:..
Human   436 YNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKEIRKKMGREPEENSKISH 500

  Fly   438 RLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPR 502
            :.:.::.....:.|...|          .|..||.:|:.:::..||..|.:             :
Human   501 KTYLVKKSNLPVHQDASE----------GEAPVQDIEKDLKQMRLQNTKES-------------K 542

  Fly   503 KPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRK-VTFKSPQKFVTY---------- 556
            .|.:.:........|:| ....::..|:  |...::::...: :||:...||..|          
Human   543 NPEQKYKAKKGVKFEIN-LDKCISDENI--LQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYT 604

  Fly   557 --GIENMPPP------------------------------AVKPAVNPPPTGVPMQMSVSSNDSG 589
              ..|.:..|                              ||....:..||| |....|...:..
Human   605 DKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTG-PDNGQVIVIEGI 668

  Fly   590 DSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPPV 654
            .......|.::..:|..:...:..||.|..:..:.|.  .|..|..|       .:|...:|..|
Human   669 PGNRKQWRHEAPGTLMSVLAAAHLTSSSFSADEEFAM--GTLKQWLP-------KEEDEGKVEMV 724

  Fly   655 ANLWTKEQKKQA-----------------------FELLAAMNAAER--EASGGGVVGSGPGGAR 694
            :.:...|::.:.                       .|.||.....|:  |||      |....:|
Human   725 SGIEVDEEQLEPRSDDDDTNFEESEDELRDEVVEYLEKLATFKGEEKTEEAS------STSKDSR 783

  Fly   695 RQHLRQSVRERNSTLQRNRMRRSLVVATGHQKLTTRDQ 732
            :...|:.:..:.|...|..:......:..|..:|..||
Human   784 KSREREGISMQKSEELREGLENISTTSNDHICITDEDQ 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nek2NP_572415.1 STKc_Nek2 18..281 CDD:270857 98/266 (37%)
S_TKc 19..281 CDD:214567 98/265 (37%)
NEK5NP_001352481.1 STKc_Nek5 3..259 CDD:173765 98/266 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D132059at33208
OrthoFinder 1 1.000 - - FOG0000168
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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