Protein Alignment Nek2 and NEK5

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_047286243.1
• Gene: NEK5 / 341676
• HGNCID: 7748
• Length: 904
• Species: Homo sapiens
• Alignment Length: 885
• Identity: 193/885 - (21%)
• Similarity: 334/885 - (37%)
• Gaps: 228/885 - (25%)

  Fly    14 KTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNI 78
            :|:..|:|:..:|.|:||..|..:.||..:....|.:|::::...:.:|...|:.:|.:::||||
Human    71 ETMDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 135

  Fly    79 VQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR---FEEPYIWRVLFQLCRALQVCHN 140
            |.:::..  :|...::||||.|.||||.:     |..|||   |.|..|.....|:...|:..|:
Human   136 VAFFNSF--QENGRLFIVMEYCDGGDLMK-----RINRQRGVLFSEDQILGWFVQISLGLKHIHD 193

  Fly   141 KIPNGTILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYD 204
            :    .|||||||..||||...|. |||||||:||:|......|.:.:|||:|:|||:.:.:.|:
Human   194 R----KILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYN 254

  Fly   205 RKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQR 269
            .|:|:|::||::||:|.|:.||.|....||..||.|..|:.|...:|.:|..:|:.:..|....|
Human   255 NKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDR 319

  Fly   270 PGIEVIIRHPLVVRNISE----------------------------------------LDGKFP- 293
            |.|..|::.|.:...|.:                                        ..||.|
Human   320 PSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPP 384

  Fly   294 -----------ILVDSGEDFYTLPSGAR-----------------------------LFEDEEED 318
                       .::...|  :..|:||:                             |.....:.
Human   385 RSRISVPIKRNAILHRNE--WRPPAGAQKARSIKMIERPKIAAVCGHYDYYYAQLDMLRRRAHKP 447

  Fly   319 GVHPELSSTMFTEQYSFNEGYGQ--RRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYE 381
            ..||      ..::.:..|.|||  |.......:..:.....|.:.:.|:...|:|.|. ||..|
Human   448 SYHP------IPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLR-PSSAE 505

  Fly   382 ---SIRREERA---EERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDE-----VL 435
               :.|:|.|:   |.|..||...:...|:||..|:.:|:.::..:..:.:.:.:..|     .:
Human   506 PNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKEIRKKMGREPEENSKI 570

  Fly   436 KTRLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIP 500
            ..:.:.::.....:.|...|          .|..||.:|:.:::..||..|.:
Human   571 SHKTYLVKKSNLPVHQDASE----------GEAPVQDIEKDLKQMRLQNTKES------------ 613

  Fly   501 PRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRK-VTFKSPQKFVTY-------- 556
             :.|.:.:........|:| ....::..|:  |...::::...: :||:...||..|
Human   614 -KNPEQKYKAKKGVKFEIN-LDKCISDENI--LQEEEAMDIPNETLTFEDGMKFKEYECVKEHGD 674

  Fly   557 ----GIENMPPP------------------------------AVKPAVNPPPTGVPMQMSVSSND 587
                ..|.:..|                              ||....:..||| |....|...:
Human   675 YTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTG-PDNGQVIVIE 738

  Fly   588 SGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKPPITQEQPAEVP 652
            .........|.::..:|..:...:..||.|..:..:.|.  .|..|..|       .:|...:|.
Human   739 GIPGNRKQWRHEAPGTLMSVLAAAHLTSSSFSADEEFAM--GTLKQWLP-------KEEDEGKVE 794

  Fly   653 PVANLWTKEQKKQA-----------------------FELLAAMNAAER--EASGGGVVGSGPGG 692
            .|:.:...|::.:.                       .|.||.....|:  |||      |....
Human   795 MVSGIEVDEEQLEPRSDDDDTNFEESEDELRDEVVEYLEKLATFKGEEKTEEAS------STSKD 853

  Fly   693 ARRQHLRQSVRERNSTLQRNRMRRSLVVATGHQKLTTRDQ 732
            :|:...|:.:..:.|...|..:......:..|..:|..||
Human   854 SRKSREREGISMQKSEELREGLENISTTSNDHICITDEDQ 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/266 (37%)
NEK5	XP_047286243.1	STKc_Nek5	75..331	CDD:173765	98/266 (37%)