DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and CG9135

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	258	Identity:	49/258 - (18%)
Similarity:	85/258 - (32%)	Gaps:	87/258 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PNGTI-LHRDIK--------PA---------------NIFLD------AAGNAKLGDFGLARMLR 177
            |:|.: |.:|||        ||               .:||.      |.|..|.|..|:.
  Fly   144 PSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFLTDTGTVYACGENKSGQCGVG---- 204

  Fly   178 RDQSFAASFVGTP-HYMSPELVKGRKYDRKSDVWAVGC-----LVYEMCALRPPFRGRAFDQLSE 236
              .:.|..:..|| :|..|.:::            :||     ::.::......|....:.||.
  Fly   205 --NTHANIYSPTPINYRGPPIIR------------IGCGAEFSVILDIKGSLHTFGLPEYGQLG- 254

  Fly   237 KIAQGEFSRIPAIYSTDLQEII-AFMLAVDHEQRPGIEVIIRHPLVVRNISELDG---------- 290
                         ::||.:..: |..|:...|..|...|:........:::.:||
  Fly   255 -------------HNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGHVTPVDGVQIVDFACGN 306

  Fly   291 KFPILVDSGEDFYTLPSG--ARLFEDEEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFT 351
            ...:.:||.:..|:...|  .||...|.:|.:.|.|.....|      :|.|.|.:.....|:
  Fly   307 NHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDT------QGRGGRSVFCGSTFS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	32/174 (18%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	32/174 (18%)
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	8/39 (21%)
		RCC1_2	171..200	CDD:290274	5/28 (18%)
		RCC1	188..236	CDD:278826	12/65 (18%)
		RCC1	239..312	CDD:278826	12/86 (14%)
		RCC1	317..366	CDD:278826	13/53 (25%)
		RCC1	414..465	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010