DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_009301513.1	Gene:	herc1 / 336598	ZFINID:	ZDB-GENE-030131-8542	Length:	4867	Species:	Danio rerio

Alignment Length:	456	Identity:	95/456 - (20%)
Similarity:	154/456 - (33%)	Gaps:	130/456 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 DHEQRP-------GIEVI-----IRHPLVVRNISELDGKFPILVDSGEDFY-----------TLP 306
            |.::||       |.||:     .:|..||.:    |||   |...|...|           .||
Zfish  4126 DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS----DGK---LFSFGNGDYGRLGLGNTSNKKLP 4183

  Fly   307 SGARLFEDEEEDGVHPELSSTMFTEQ-----YSFNEG-YGQRRL-SVTGVFTPDLRSELFYSAKR 364
            ......|..:...|...|:.|:....     ::|.:| ||:..| :.|...:|.....|.....:
Zfish  4184 ERVSALEGHQVGQVACGLNHTLAVSADGMTVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIK 4248

  Fly   365 KIFPAKKLQLS---DPSLYESIRREERAEERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRAL 426
            |:....:..::   |.::|..      .::|.:.|.|.|.|..::.||         .|    ||
Zfish  4249 KVACGTQFSVALTKDGNVYTF------GQDRLIGLPEGRARNHNRPQQ---------VP----AL 4294

  Fly   427 TQNIFDEVLKTRLHAIRAQESLLQQKLEEL----QTREQELQLAEQ---RVQTLERQMQEKLLQQ 484
            |....::|      |:.|:.:|......::    ...|.:|.|...   |..||...:|.|.:||
Zfish  4295 TGVFIEDV------AVGAEHTLTLSSTGDVYAWGSNSEGQLGLGHTNHVREPTLISALQGKNIQQ 4353

  Fly   485 -EKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLP--APKSLNTLRKVT 546
             ....|......|||:|||.|..|                  ..|.|. ||  .|...:.||:|:
Zfish  4354 ISAGRCHSAAWTAPPVPPRAPGSS------------------VPLQLG-LPVCVPPQYSALREVS 4399

  Fly   547 FK------------SPQKFVTYGIENMPP------------------PAVKPAVNPPPTGVPMQM 581
            .:            |...:.::.:.|:.|                  ..::|.:.|....:||..
Zfish  4400 MEALRARLRLLYHFSDLMYSSWRLLNLSPNNQSCTSRYNAGTWGIVQGQLRPLLAPRVYTLPMVR 4464

  Fly   582 SVSSN-DSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKPPITQ 645
            |:... ..|.:.......|.|     .:||.|.....:....||.:..|:.::.|..|.|..:..
Zfish  4465 SIGKTMVQGKNYGPQITVKRI-----STRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVG 4524

  Fly   646 E 646
            |
Zfish  4525 E 4525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	7/27 (26%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	7/27 (26%)
herc1	XP_009301513.1	RCC1	369..726	CDD:332518
		SPRY_HERC1	2004..2161	CDD:293939
		UBA_HERC1	2729..2772	CDD:270584
		WD40	3406..3773	CDD:330360
		WD40 repeat	3419..3452	CDD:293791
		WD40 repeat	3479..3514	CDD:293791
		WD40 repeat	3527..3569	CDD:293791
		WD40 repeat	3575..3611	CDD:293791
		WD40 repeat	3618..3660	CDD:293791
		WD40 repeat	3665..3710	CDD:293791
		WD40	3737..>3831	CDD:330360
		WD40 repeat	3749..3784	CDD:293791
		RCC1	4004..4351	CDD:332518	55/256 (21%)
		HECTc	4479..4847	CDD:238033	12/52 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010