Protein Alignment Nek2 and Nek5

DIOPT Version :9

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_006509217.1
• Gene: Nek5 / 330721
• MGIID: 2142824
• Length: 661
• Species: Mus musculus
• Alignment Length: 557
• Identity: 151/557 - (27%)
• Similarity: 244/557 - (43%)
• Gaps: 121/557 - (21%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :.::.::.::|.|:||..|..:|||.......|.::..:..||.    .:|:.:|.:::|||||.
Mouse     1 MDNFHLIKIIGEGTFGKVYLAKDKSESSHCVIKEISLTKEKEAS----KNEVILLARMEHPNIVT 61

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            ::...  :|...::||||.|.||||.|.:||.|.  ..|.|..|.....|:...|:..|::
Mouse    62 FFSSF--QENGRLFIVMEYCDGGDLMQRIQRQRG--VMFSEDQILCWFVQISLGLKHIHDR---- 118

  Fly   146 TILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
            .|||||||..||||...|. |||||||.||.|......|.:..|||:|:|||:.:.|.|:.|:|:
Mouse   119 KILHRDIKSQNIFLSKNGMVAKLGDFGTARTLNDSMELAQTCAGTPYYLSPEICQNRPYNNKTDI 183

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            |::||::||:|.|:.||....|..|..||.||..:.|...:|.|||.:|..:..|..:.||.:..
Mouse   184 WSLGCVLYELCTLKHPFESNNFHHLVLKICQGRVAPISPHFSRDLQSLIPQLFRVSPQDRPSVTS 248

  Fly   275 IIRHP----LVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPE---LSSTMFTEQ 332
            :::.|    |:.|::                 |......|:     :...|.|   :..|.....
Mouse   249 LLKRPFLETLIARSL-----------------YPEVCSRRI-----QSHAHMENMAIGPTACWRV 291

  Fly   333 YSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLS----DPSLYESIRREERAEERQ 393
            ..::..|.||:               |.:.:.|:...::|.|.    :|...|..:.:...||.:
Mouse   292 SPWSAAYLQRK---------------FEAQQYKLKVERQLGLRPSSVEPHPNEGEKLQSHWEETK 341

  Fly   394 VELAEERRRK-KDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQ----KL 453
            .:..:.|:.| ||||..|:.:|:        |....|...|:.|.....::...:|..:    |.
Mouse   342 FQELQYRKNKMKDQEYWKQLEEI--------RQQYHNDMKEIKKKMGRELKESANLSHRTYLVKR 398

  Fly   454 EELQTREQ--ELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTI 516
            ..|.:|..  |.::::|||...|..: :|.:.:|.                            |:
Mouse   399 SNLSSRPDAPEEEVSKQRVVKFEISL-DKCISEED----------------------------TV 434

  Fly   517 ELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKF 553
            :.||   .|.||| |||            :|:...||
Mouse   435 QENE---AVDKLN-ATL------------SFEDGTKF 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	97/267 (36%)
		S_TKc	19..281	CDD:214567	97/266 (36%)
Nek5	XP_006509217.1	STKc_Nek5	3..255	CDD:173765	97/263 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950