DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nek2 and Herc2

DIOPT Version :9

Sequence 1:NP_572415.1 Gene:Nek2 / 31696 FlyBaseID:FBgn0029970 Length:735 Species:Drosophila melanogaster
Sequence 2:XP_006229362.1 Gene:Herc2 / 308669 RGDID:1307989 Length:4836 Species:Rattus norvegicus


Alignment Length:649 Identity:121/649 - (18%)
Similarity:207/649 - (31%) Gaps:211/649 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 HNKIPNGTIL-------HR----DIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAAS-FVGTPH 191
            |...|.||.:       ||    |...|  ||.|..:..:.|:.:...|.:.:.:... .:.||.
  Rat  1364 HCSSPGGTPISKSRLCSHRWALGDHSQA--FLQAIADNNIQDYNVKDFLCQIERYCRQCHLTTPI 1426

  Fly   192 YMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQE 256
            ...||          ..|..||.|:  :|.|                          :...||..
  Rat  1427 TFPPE----------HPVEEVGRLL--LCCL--------------------------LKHEDLGH 1453

  Fly   257 IIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDG-V 320
            :   .|::.|....|||. ::|..:.:.:          ||.....|  .:...|.:..:|.| .
  Rat  1454 V---ALSLVHVGTLGIEQ-VKHRALPKAV----------VDVCRVVY--QAKCSLIKTHQEQGRS 1502

  Fly   321 HPELSSTMFTE-QYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIR 384
            :.|:.:.:... ::.|||            ..|.:.|:|...:|.|             |..|:.
  Rat  1503 YKEVCAPVIERLRFLFNE------------LRPAVCSDLSIMSKFK-------------LLGSLP 1542

  Fly   385 REERAEERQVELAEERRRKK--------DQEQQKRDQE-------LLKEAP----------SSPR 424
            |..|..::   :..|||||:        |.|::..::|       :|..:|          .||:
  Rat  1543 RWRRIAQK---IIRERRRKRVPKKPESTDGEEKIGNEESDLEEACVLPHSPINVDKRPISMKSPK 1604

  Fly   425 ALTQNIFDEV--------LKTRLHAIRAQESLLQQKLEELQTRE------------QELQLAEQR 469
            ...|.:.:.|        ||..:..:..|.:||...:|.....|            ::|:.||.|
  Rat  1605 DKWQPLLNTVTGVHKYKWLKQNVQGLYPQSALLNTIVEFALKEEPVDVEKMRKCLLKQLERAEVR 1669

  Fly   470 VQ----TLERQMQEKLLQQEKHT--CSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSP----- 523
            ::    .|:...:..||...::.  |..::.|...|...:|.      |.|..:::...|     
  Rat  1670 LEGIDTILKLAAKSFLLPSVQYAMFCGWQRLIPEGIDIGEPL------TDCLRDVDLIPPFNRML 1728

  Fly   524 ---TVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSS 585
               |..||      ...::..:|.|...:..||...||:                .||:|...:.
  Rat  1729 LEVTFGKL------YAWAVQNIRSVLMDASAKFKELGIQ----------------PVPLQTITNE 1771

  Fly   586 NDSGDSQASSTRRKSI---LSLFGLSRGSK------------ATSKSLPSVNQVAQAAATRVQRP 635
            |.:|.|..:..:.:.:   ||:..|..|:.            .|..:|..:.....:....:...
  Rat  1772 NPAGPSLGTIPQARFLLVMLSMLTLQHGANNLDLLLNSGTLALTQTALKLIGPTCDSVEDDMNAS 1836

  Fly   636 PLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELLAAMNAAEREASG-----GGVVGSGPGGAR 694
            .......:.:|...|..||      :......||.|.|....|...|     |...|..||..|
  Rat  1837 ARGASATVLEETRKETAPV------QLPVSGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGR 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nek2NP_572415.1 STKc_Nek2 18..281 CDD:270857 31/153 (20%)
S_TKc 19..281 CDD:214567 31/153 (20%)
Herc2XP_006229362.1 ATS1 <494..787 CDD:227511
Cyt-b5 1212..1283 CDD:395121
MIB_HERC2 1871..1931 CDD:399589 7/24 (29%)
UBA_HERC2 2461..2508 CDD:270585
Cul7 2555..2632 CDD:402903
SH3_15 2640..2697 CDD:408152
ZZ_HERC2 2707..2751 CDD:239084
APC10-HERC2 2766..2911 CDD:176485
ATS1 2957..3323 CDD:227511
ATS1 4025..4330 CDD:227511
HECTc 4423..4794 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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