Protein Alignment Nek2 and Nek3

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_006253421.1
• Gene: Nek3 / 306576
• RGDID: 1307419
• Length: 471
• Species: Rattus norvegicus
• Alignment Length: 504
• Identity: 140/504 - (27%)
• Similarity: 235/504 - (46%)
• Gaps: 91/504 - (18%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGM----NYDELDEAKCDALVSEISVLRQLQHP 76
            :.:|.||.|:|:||||:.....:||:.:.||.|.:    ::.::...:.:|:     :|.:::||
  Rat     1 MDNYTVLRVIGHGSFGSVLLATEKSSNQTFAMKEIRLLKSFSDVQNCRKEAV-----LLAKMKHP 60

  Fly    77 NIVQYYHHLVNREAKS-VYIVMECCAGGDLAQIVQRARSQRQR-FEEPYIWRVLFQLCRALQVCH 139
            |||.:....   ||:. :|||||.|.||||   .||.:.|:.: |.|..:.....|:|..:...|
  Rat    61 NIVAFKESF---EAEGHLYIVMEYCDGGDL---TQRIKQQKGKLFPEDTVLNWFIQICLGVNHIH 119

  Fly   140 NKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYD 204
            .:    .:||||||..|:||...|..||||||.||:|....:||.::||||:|:.||:.:...|:
  Rat   120 KR----RVLHRDIKSKNVFLTHDGKVKLGDFGSARLLSSPMAFARTYVGTPYYVPPEIWENLPYN 180

  Fly   205 RKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQR 269
            .|||:|::||::||:|||:.||:..::..|..||.||....:||:||:.||.::..||..:...|
  Rat   181 NKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSSKLQCLVKQMLKRNPVHR 245

  Fly   270 PGIEVIIRH----PLVVRNISELDGKFPILVDSGEDF-----YTLPSGARLFEDEEEDGVHPE-- 323
            |....::..    |||::.:..     .|:.:.||..     .:.|...:    ::|.|..||
  Rat   246 PSATTLLCRGSLAPLVLKCLPP-----QIIREYGEQILDEVKISKPQNVK----KQESGNPPEPP 301

  Fly   324 LSSTMFTEQYSFNEGYGQ----RRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIR 384
            .:::..:......|.||.    ..|....:.|....:|
  Rat   302 RNASPASPHRQRWERYGPSSAVAALEKASILTSSFTAE--------------------------- 339

  Fly   385 REERAEERQVELAEER-RRKKDQEQQKRDQELLKEAPSSPRALTQNIF----DEVLKTRLHAIRA 444
             ::||....::.:||. ||:..:|..:....:||.|..|....|..|.    :..||..|....|
  Rat   340 -DDRAGGSVIKYSEENARRQWVREPPEALLSMLKGADLSLAFQTYTIHRPGTEGFLKGPLSEDTA 403

  Fly   445 QESL-------------LQQKLEELQTREQELQLAEQRVQTLERQMQEK 480
            .:|:             .:.:|:|..|..:|.......|..|::|:.::
  Rat   404 SDSVDGDLDSVLVDPERFEPRLDEEDTDFEEDDENPDWVSELKKQVGQR 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	99/272 (36%)
Nek3	XP_006253421.1	Protein Kinases, catalytic domain	3..257	CDD:473864	98/268 (37%)