Protein Alignment Nek2 and Nek1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_038950287.1
• Gene: Nek1 / 290705
• RGDID: 1309375
• Length: 1261
• Species: Rattus norvegicus
• Alignment Length: 754
• Identity: 184/754 - (24%)
• Similarity: 296/754 - (39%)
• Gaps: 192/754 - (25%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|..|..:|.||||....|:....|..:..|.:|...:.:.:.:....|::||..::||||||
  Rat     1 MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKEREESRREVAVLANMKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
  Rat    66 YKESF--EENGSLYIVMDYCEGGDL---FKRINAQKGTLFQEDQILDWFVQICLALKHVHDR--- 122

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
  Rat   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:|.|:..|.......|..||..|.|..:...||.||:.:::.:...:...||.:..
  Rat   187 WALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNS 251

  Fly   275 IIRHPLVVRNISELDGKF--PILVDSGEDF----------YTLPSGARLFEDEEEDGVHPELSST 327
            |:....:.:.|.    ||  |.|:  .|:|          ..:| |.|....:......|....|
  Rat   252 ILEKGFIAKRIE----KFLSPQLI--AEEFCLKTVSKFGPQPIP-GKRPASGQGVSSFVPAQKIT 309

  Fly   328 MFTEQYSF---NEGYGQRRLSVTGVFTPDLRSELFYSAKRK---IFPAKKLQLSDPSLYESIRRE 386
            ..:.:|..   .:.||.::|           .|.....|.|   ..|.||:...:.....|   |
  Rat   310 KPSAKYGVPITYKKYGDKKL-----------LEKKPPPKHKQAHQIPVKKMNSGEERKKMS---E 360

  Fly   387 ERAEERQVELAEERRRKKDQ------EQQKRDQE------------------------------- 414
            |.|::|::|..|:.:::|||      ||.||.::
  Rat   361 EAAKKRRLEFIEKEKKQKDQIRFLKAEQLKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFF 425

  Fly   415 ----LLKEAPSSPRALTQN---IFDEVLKTR------------------------LHAIRAQ--E 446
                .:..:|.|||...::   |||::.:.|                        |...||:  |
  Rat   426 GSGGAVSPSPCSPRGQYEHYHAIFDQMQQLRAEDNEARWKGRIYGRWLPERQKGHLGVERAKQVE 490

  Fly   447 SLLQQKLEELQ--------------------------------TREQELQLAEQRVQTLE----- 474
            ..||:|.|.:|                                .:|:|:.||..|...|:
  Rat   491 EFLQRKQEAMQNKARAEGHVGILQNLASLYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNER 555

  Fly   475 RQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSL 539
            :|::.||..:.|....              .|.........:.|.:.....|:.|.......:.|
  Rat   556 QQIKAKLRGENKEAGG--------------TKGQDATEEADMRLKKMESLKAQANARAAVLKEQL 606

  Fly   540 NTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDSGDSQASSTRRKSILS- 603
            ...||..::..:|.    .|......||.:..||        |:..:::|.| .|..:.|.::|
  Rat   607 ERKRKEAYEREKKV----WEEHLVVRVKSSDVPP--------SMEHHEAGGS-PSQQQMKPVISV 658

  Fly   604 --------LFGLSRGSKATSKSLPSVNQVAQAAATRVQR 634
                    |.|....|:.||:.:...|....:....::|
  Rat   659 TSALKEVGLDGSLTESQETSEEMEKSNNAISSKREILRR 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)
Nek1	XP_038950287.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)