DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and SERGEF

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_036271.1	Gene:	SERGEF / 26297	HGNCID:	17499	Length:	458	Species:	Homo sapiens

Alignment Length:	55	Identity:	15/55 - (27%)
Similarity:	25/55 - (45%)	Gaps:	8/55 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESAGMDFSQK----TLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDEL 55
            |:|.:...||    ..|:.:|.|:..    |..:.|....||::|.|...:|.:|
Human   247 EAAFLPVPQKIEAHCFQNEKVTAIWS----GWTHLVAQTETGKMFTWGRADYGQL 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	10/38 (26%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	10/37 (27%)
SERGEF	NP_036271.1	RCC1 1	15..67
		RCC1	23..64	CDD:278826
		RCC1 2	68..119
		RCC1	68..116	CDD:278826
		RCC1_2	103..132	CDD:290274
		RCC1	119..167	CDD:278826
		RCC1 3	120..171
		RCC1 4	172..230
		RCC1_2	219..243	CDD:290274
		RCC1 5	231..283		9/39 (23%)
		RCC1	231..279	CDD:278826	8/35 (23%)
		RCC1 6	284..351		5/14 (36%)
		RCC1	284..348	CDD:278826	5/14 (36%)
		RCC1	351..399	CDD:278826
		RCC1 7	352..402
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010